Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae).
Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae).
复制标题
DOI：
10.1186/s13071-017-2232-3
复制
发表时间：
2017-06-29
影响因子：
3.2
通讯作者：
Lee CY
中科院分区：
文献类型：
--
作者：
Dang K;Doggett SL;Veera Singham G;Lee CY
臭虫在世界范围内的复苏[包括温带臭虫Cimex lectularius L.和Cimex hemipterus（F.）]在过去二十年中，人们认为这在很大程度上是由于杀虫剂抗药性的发展。自2010年以来的转录组学和基因组学研究，以及形态学，生物化学和行为学研究，有助于臭虫的杀虫剂抗性研究。多种抗性机制，包括通过角质层增厚或重塑产生的渗透抗性、通过解毒酶（例如细胞色素P450单加氧酶和酯酶）活性增加产生的代谢抗性以及通过kdr突变产生的敲低抗性，已被实验确定为赋予臭虫杀虫剂抗性。可能存在其他候选抗性机制，包括行为抗性、某些类型的生理抗性（例如通过点突变增加酯酶的活性、谷胱甘肽S-转移酶、靶位点不敏感性，包括改变的AChE、GABA受体不敏感性和改变的nAChR）、共生体介导的抗性和其他潜在的尚未发现的机制。本文综述了臭虫的抗药性机制、抗药性基因、潜在的候选抗药性机制以及监测抗药性的方法。本文提供了一个深入了解杀虫剂抗性管理（杀虫剂）和害虫综合管理（IPM）战略的发展，成功的臭虫管理的知识。
The worldwide resurgence of bed bugs [both Cimex lectularius L. and Cimex hemipterus (F.)] over the past two decades is believed in large part to be due to the development of insecticide resistance. The transcriptomic and genomic studies since 2010, as well as morphological, biochemical and behavioral studies, have helped insecticide resistance research on bed bugs. Multiple resistance mechanisms, including penetration resistance through thickening or remodelling of the cuticle, metabolic resistance by increased activities of detoxification enzymes (e.g. cytochrome P450 monooxygenases and esterases), and knockdown resistance by kdr mutations, have been experimentally identified as conferring insecticide resistance in bed bugs. Other candidate resistance mechanisms, including behavioral resistance, some types of physiological resistance (e.g. increasing activities of esterases by point mutations, glutathione S-transferase, target site insensitivity including altered AChEs, GABA receptor insensitivity and altered nAChRs), symbiont-mediated resistance and other potential, yet undiscovered mechanisms may exist. This article reviews recent studies of resistance mechanisms and the genes governing insecticide resistance, potential candidate resistance mechanisms, and methods of monitoring insecticide resistance in bed bugs. This article provides an insight into the knowledge essential for the development of both insecticide resistance management (IRM) and integrated pest management (IPM) strategies for successful bed bug management.