Long-term outcome of endoscopic balloon dilation in obstructive gastrointestinal Crohn's disease: a prospective long-term study.
Long-term outcome of endoscopic balloon dilation in obstructive gastrointestinal Crohn's disease: a prospective long-term study.
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DOI：
10.1155/dte.6.67
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Yao, T
中科院分区：
文献类型：
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作者：
Matsui, T;Ikeda, K;Tsuda, S;Yao, K;Sou, S;Satoh, S;Hatakeyama, S;Matake, H;Sakurai, T;Yao, T
研究背景：探讨球囊扩张治疗克罗恩病合并非吻合口梗阻性胃肠道病变的近期和远期疗效。材料与方法对55例有梗阻性胃肠道病变的克罗恩病患者行鼻内窥镜气囊扩张术。短期结果：8次扩张失败，症状没有缓解(14.5%)。结果远期预后40例，随访6个月以上(平均37个月)，未吻合口狭窄占59.0%。40例患者中有31例(78%)有可能避免手术。分别有92%、81%和77%的患者在一年、两年和三年后避免了手术(Kaplan-Meier方法)。在没有事先手术的情况下，吻合口狭窄和狭窄之间的长期结果没有差别。结论本研究结果提示：(1)未经手术治疗的狭窄和吻合口狭窄均可用此方法治疗；(2)如果长期随访，70%以上的梗阻性胃肠道克罗恩病患者可以避免手术。
Background The short- and long-term results of balloon dilation therapy in Crohn's patients with non-anastomotic obstructive gastrointestinal lesions are investigated. Materials and methods Fifty-five patients with Crohn's disease who had obstructive gastrointestinal lesions were treated prospectively by endoscopic balloon dilation. Short-term results Eight of the initial dilations were unsuccessful giving no symptomatic relief (14.5%). Long-term results The subjects of the long-term prognosis were 40 cases followed up for more than 6 months (average 37 months) and their strictures were non-anastomotic in more than half (59%). Avoidance of surgery, was possible in 31 of 40 patients (78%). Surgery was avoided in 92%, 81% and 77% of patients after one, two, and three years, respectively (Kaplan–Meier's method). There was no difference in long-term outcome between anastomotic strictures and strictures in the absence of prior surgery. Conclusion Our results suggest that, (1) strictures in the absence of prior surgery might be treated in this way as well as anastomotic strictures; (2) if followed for a prolonged time period, more than 70% of patients, who have undergone balloon dilation for obstructive gastrointestinal Crohn's disease, may be able to avoid surgery.