Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation
Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation
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DOI：
10.1016/j.jneuroim.2003.10.054
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发表时间：
2004-03-01
影响因子：
3.3
通讯作者：
Wang, XM
中科院分区：
文献类型：
--
作者：
Li, FQ;Lu, XZ;Wang, XM
越来越多的证据表明，大脑炎症参与了帕金森病的发病机制。雷公藤甲素是中药雷公藤甲素的主要活性成分之一，具有有效的抗炎和免疫抑制特性。我们发现雷公藤甲素浓度依赖性地减弱了脂多糖（LPS）诱导的[H-3]多巴胺摄取减少和原代中脑神经元/神经胶质混合培养物中酪氨酸羟化酶免疫反应性神经元的损失。雷公藤甲素还可以阻断 LPS 诱导的小胶质细胞激活以及 TNFα 和 NO 的过量产生。我们的数据表明，雷公藤甲素可以保护多巴胺能神经元免受脂多糖诱导的损伤，其抑制小胶质细胞激活的效率可能是该机制的基础。 (C) 2003 Elsevier B.V. 保留所有权利。
Mounting lines of evidence have suggested that brain inflammation participates in the pathogenesis of Parkinson's disease. Triptolide is one of the major active components of Chinese herb Tripterygium wilfordii Hook F, which possesses potent anti-inflammatory and immunosuppressive properties. We found that triptolide concentration-dependently attenuated the lipopolysaccharide (LPS)-induced decrease in [H-3]dopamine uptake and loss of tyrosine hydroxylase-immunoreactive neurons in primary mesencephalic neuron/glia mixed culture. Triptolide also blocked LPS-induced activation of microglia and excessive production of TNFalpha and NO. Our data suggests that triptolide may protect dopaminergic neurons from LPS-induced injury and its efficiency in inhibiting microglia activation may underlie the mechanism. (C) 2003 Elsevier B.V. All rights reserved.