Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter
Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter
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DOI：
10.1152/ajpheart.00935.2005
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发表时间：
2006-04-01
影响因子：
4.8
通讯作者：
Stergiopulos, N
中科院分区：
文献类型：
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作者：
Jegger, D;Jeanrenaud, X;Stergiopulos, N
心肌梗死(MI)的啮齿动物模型被广泛应用于心力衰竭的研究。然而，超声心动图左心室(LV)功能参数，如心肌功能指数(MPI)及其与短轴缩短率(LVFS/MPI)之比的长期随访尚未与有创指标(如来自电导导管(CC)的指标)相结合进行验证。将结扎左冠状动脉前降支的SD大鼠(n=9)与非MI的假手术对照组(n=10)进行比较。每隔2wk行一次经胸超声心动图(TTE)，持续8wk，比较经典的TTE参数，特别是MPI和LVFS/MPI，并与经胸超声心动图(CC)获得的有创指标进行比较。连续的TTE数据显示，在MI存在的情况下，所研究的大多数非侵入性功能和结构参数(经典的和新的)都发生了显著变化。MPI和LVFS/MPI均与体重(MPI和LVFS/MPI分别为-0.58和0.76)、每搏前负荷做功(r=-0.61和0.63)、LVEDP(r=0.82和-0.80)、舒张末容量(r=0.61和-0.58)、收缩末期容量(r=0.46和-0.48)显著相关(P<；0.05)。多元线性回归分析显示，LVEDP是MPI(r=0.84)和LVFS/MPI(r=0.83)的唯一独立决定因素。我们得出结论，MPI和LVFS/MPI与经典的无创性TTE参数具有很强的相关性，并且比经典的无创性TTE参数更好地与已建立的、无创性评估的收缩能力、前负荷和容量测定指标相关联。这些发现支持使用这两个新的无创性指标对心肌梗死后左室重构进行长期分析。
The rodent model of myocardial infarction (MI) is extensively used in heart failure studies. However, long-term follow-up of echocardiographic left ventricular (LV) function parameters such as the myocardial performance index (MPI) and its ratio with the fractional shortening (LVFS/MPI) has not been validated in conjunction with invasive indexes, such as those derived from the conductance catheter (CC). Sprague-Dawley rats with left anterior descending coronary artery ligation (MI group, n = 9) were compared with a sham-operated control group (n = 10) without MI. Transthoracic echocardiography (TTE) was performed every 2 wk over an 8-wk period, after which classic TTE parameters, especially MPI and LVFS/MPI, were compared with invasive indexes obtained by using a CC. Serial TTE data showed significant alterations in the majority of the noninvasive functional and structural parameters (classic and novel) studied in the presence of MI. Both MPI and LVFS/MPI significantly (P < 0.05 for all reported values) correlated with body weight (r = -0.58 and 0.76 for MPI and LVFS/MPI, respectively), preload recruitable stroke work (r = -0.61 and 0.63), LV end-diastolic pressure (LVEDP) (r = 0.82 and -0.80), end-diastolic volume (r = 0.61 and -0.58), and end-systolic volume (r = 0.46 and -0.48). Forward stepwise linear regression analysis revealed that, of all variables tested, LVEDP was the only independent determinant of MPI (r = 0.84) and LVFS/MPI (r = 0.83). We conclude that MPI and LVFS/MPI correlate strongly and better than the classic noninvasive TTE parameters with established, invasively assessed indexes of contractility, preload, and volumetry. These findings support the use of these two new noninvasive indexes for long-term analysis of the post-MI LV remodeling.