EFFECT OF TRAINING ON PHYSICAL EXERCISE-INDUCED CHANGES IN NON-SPECIFIC HUMORAL IMMUNITY
EFFECT OF TRAINING ON PHYSICAL EXERCISE-INDUCED CHANGES IN NON-SPECIFIC HUMORAL IMMUNITY
复制标题
训练对体育锻炼引起的非特异性体液免疫变化的影响
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
K. Sugawara
中科院分区：
文献类型：
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作者：
T. Kumae;S. Kurakake;K. Machida;K. Sugawara
尽管人们普遍认为习惯性锻炼可以保护个人免受感染，但很少进行仔细的科学研究。为了明确体能训练对非特异性体液免疫的影响，对18名健康男性志愿者进行为期10周的训练前后血清调理活性（作为非特异性体液免疫强度的更直接指标）和血清免疫球蛋白和补体水平进行检测，作为免疫防御指标。训练前和训练后比较运动前和运动后立即的三种免疫球蛋白（IgG、IgA和1gM）和一种补体（C3）的血清水平。配对t检验显示，训练前运动引起的IgG和C 3 显着增加，训练后IgG、IgA、IgM和C 3 显着增加。但这些免疫球蛋白和补体的基线（运动前）水平在训练期间显着受到抑制。以与血清蛋白水平相同的方式相互比较血清调理活性。作为血清调理活性指标之一的嗜中性化学发光峰高度（PH）在训练开始阶段运动后立即显着下降。训练期结束后，血清调理活性没有显示出明显的运动引起的变化，训练期间基线水平略有增加。这些发现表明，对身体压力的抵抗力和反应能力得到提高，非特异性体液免疫、抵抗感染的自卫能力被认为通过训练得到提高。 (Jpn. J. Phys. Fitness Sports Med. 1994, 43 : 7583) 关键词：鲁米诺依赖性化学发光、血清调理活性、血清免疫球蛋白和补体水平
Although it is generally thought that habitual exercise protects an individual from infections, few careful scientific studies have been conducted. To clarify the influences of physical training on non-specific humoral immunity, both serum opsonic activity, which is a more direct indicator for the strength of non-specific humoral immunity to infections, and serum immunoglobulin and complement levels of 18 healthy male volunteers were assayed before and after a 10-week of training as indices of immuno defense. The serum levels of three immunoglobulins (IgG, IgA and 1gM) and one complement(C3) were compared prior to and immediately after exercise both before and after training. Paired t-test revealed that before training exercise-induced increases in IgG and C 3 were significant and after training increases in IgG, IgA, IgM and C 3 were significant. But baseline (prior to exercise) levels of these immunoglobulins and complement were significantly suppressed during the training period. Serum opsonic activity was compared with each other in the same way as serum protein levels. The noutrophilic chemiluminescence Peak Height (PH), which is one of the indicators of serum opsonic activity, was significantly decreased immediately after exercise at the beginning stage of the training. After the training period, serum opsonic activity showed no noteworthy exercise-induced variations and baseline levels were slightly increased during the training period. These findings suggest that resistance and reactivity to the physical stress are improved and the non-specific humoral immunity, self-defense ability against infections, is considered to be improved by the training. (Jpn. J. Phys. Fitness Sports Med. 1994, 43 : 7583) key words : Luminol-dependent Chemiluminescence, Serum Opsonic Activity, Serum Immu noglobuli n and Complement levels