Neutrophil Granulocyte Functions in the Elderly
Neutrophil Granulocyte Functions in the Elderly
复制标题
老年人中性粒细胞的功能
DOI：
10.1007/978-1-4020-9063-9_22
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
L. Rink
中科院分区：
文献类型：
--
作者：
P. Uciechowski;L. Rink
随着年龄的增长，免疫反应会减弱。特别是适应性免疫系统淋巴细胞功能的改变已被广泛研究。65岁以下的老年人易患炎症和感染，发病率和死亡率比年轻人高。在过去的几年里，人们发现先天免疫系统的某些功能随着年龄的增长而改变，先天免疫系统是抵御病原微生物的第一道防线。在先天免疫系统的细胞中，嗜中性粒细胞（多形核白细胞、PMN、中性粒细胞）清除入侵的细菌和真菌，在免疫反应的调节中发挥着公认的重要作用。体外研究表明，老年人的中性粒细胞功能，如吞噬、活性氧（ROS）的产生、细胞内杀伤、脱颗粒，以及可能的趋化性都发生了变化，而与年轻人相比，循环中性粒细胞的数量没有改变。然而，不同研究者关于上述功能的报告数据有时存在争议。这可能是由于使用不同的中性粒细胞分离方法，污染细胞的程度和分离过程中中性粒细胞的预激活。结果表明，大多数中性粒细胞粘附表面分子和受体的功能和表达不受年龄的影响。但越来越多的证据表明，年龄相关的变化会影响受体依赖的信号转导和膜的含量和流动性，从而导致功能下降和细胞凋亡的抑制。进一步的研究必须确定负责人类中性粒细胞年龄相关调节的分子机制。
The immune response weakens during aging. Especially, the altered functions of the lymphocytes of the adaptive immune system have been extensively studied. Aged persons > 65 years display a predisposition to inflammation and infection combined with an increase in morbidity and mortality than younger individuals. In the past few years it has been discovered that certain functions of the innate immune system, which build the first line of defense against pathogenic microorganisms, are altered with aging. Among the cells of the innate immune system, neutrophilic granulocytes (polymorphonuclear leukocytes, PMN, neutrophils) eliminate invaded bacteria and fungi and play an accepted important role in regulation of the immune response. In vitro studies demonstrate that neutrophilic functions such as phagocytosis, generation of reactive oxygen species (ROS), intracellular killing, degranulation, and possibly chemotaxis are changed in elderly persons whereas the number of circulating neutrophils are unaltered compared to young persons. However, the reported data of different investigators regarding the above-mentioned functions are sometimes controversial. This may result from the use of different isolation methods of neutrophils, the degree of contaminating cells and preactivation of neutrophils during isolation. It could be shown that most of the adhesion surface molecules and receptors of neutrophils are not impaired in function and expression with age. But there is increasing evidence that age-related changes affect receptor-dependent signal transduction and membrane content and fluidity, which in turn lead to a decline in function and in inhibition of apoptosis. Further research has to be done to identify the molecular mechanisms that are responsible for the age-related modulations in human neutrophils.
影响因子：
20.3
作者：
D. Lipschitz;K. Udupa;S. Indelicato;M. Das
通讯作者：
D. Lipschitz;K. Udupa;S. Indelicato;M. Das
人多形核白细胞中的趋化受体功能被膜流化剂不同程度地改变。
DOI：
10.1073/pnas.79.19.5906
发表时间：
1982
影响因子：
11.1
作者：
Yuli,I;Tomonaga,A;Synderman,R
通讯作者：
Synderman,R