Polymorphisms of CCR5 gene in a southern Chinese population and their effects on disease progression in HIV infections.
Polymorphisms of CCR5 gene in a southern Chinese population and their effects on disease progression in HIV infections.
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中国南方人群 CCR5 基因多态性及其对 HIV 感染疾病进展的影响。
DOI：
10.1097/00002030-200212060-00016
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发表时间：
2002
期刊：
影响因子：
3.8
通讯作者：
Shui
中科院分区：
文献类型：
--
作者：
B. Zheng;Xiuqing Zhao;Naijun Zhu;Chi;K. Wong;K. Chan;W. Yam;K. Yuen;Shui
在中国南方人群中发现了7个CCR5基因突变等位基因，其中6个为新突变。最常见的是在21名健康供体和20名HIV患者中发现的杂合突变等位基因（R223Q）。在健康献血员（0.044）和HIV患者（0.041）之间没有观察到显著差异的突变频率，但在无症状（0.066）中的频率显著高于有症状的HIV患者（0.019）。
Seven mutant alleles of the CCR5 gene were identified in southern Chinese, six of which were novel mutations. The most common was a heterozygous mutant allele (R223Q) found in 21 healthy donors and 20 HIV patients. No significant difference in the mutant frequency was observed between healthy donors (0.044) and HIV patients (0.041), but the frequency was significantly higher in asymptomatic (0.066) than in symptomatic HIV patients (0.019).