Neurochemical studies in the hypoxic brain: substance P, met-enkephalin, GABA and angiotensin converting enzyme.
Neurochemical studies in the hypoxic brain: substance P, met-enkephalin, GABA and angiotensin converting enzyme.
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缺氧大脑中的神经化学研究：P 物质、甲硫脑啡肽、GABA 和血管紧张素转换酶。
DOI：
10.1016/0024-3205(81)90268-x
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发表时间：
1981
期刊：
影响因子：
6.1
通讯作者：
P. Emson
中科院分区：
文献类型：
--
作者：
A. Arregui;G. Barer;P. Emson
28日龄大鼠暴露于中度低氧(10%氧气)3周后，黑质P物质和甲硫氨酸脑啡肽的免疫反应水平显著升高，而纹状体、下丘脑苍白球无明显变化。然而，从低氧中恢复15天后，这些变化不再明显。长期、中度低氧暴露会影响大脑中可能的神经递质水平，根据目前的发现，黑质或纹状体-黑质通路似乎特别脆弱。
Exposure of 28 day old rats to moderate hypoxia (10% oxygen) for three weeks led to significant increases of immunoreactive levels of substance P and met-enkephalin in the substantia nigra but not in the corpus striatum, globus pallidus of hypothalamus.A similar group of animals exposed to hypoxia for three weeks showed decreased angiotensin converting enzyme activity in the corpus striatum and substantia nigra and decreased GABA levels in the substantia nigra. However, fifteen days after recovery from hypoxia these changes were no longer apparent.Exposure to chronic, moderate hypoxia can affect levels of putative neurotransmitters in the brain, and based on the present findings the substantia nigra or the striato-nigral pathways appear to be particularly vulnerable.