THE IMMUNOHISTOCHEMICAL EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA CYCLIN) IN MALIGNANT AND BENIGN EPITHELIAL OVARIAN NEOPLASMS AND CORRELATION WITH PROGNOSIS
THE IMMUNOHISTOCHEMICAL EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA CYCLIN) IN MALIGNANT AND BENIGN EPITHELIAL OVARIAN NEOPLASMS AND CORRELATION WITH PROGNOSIS
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DOI：
10.1016/0959-8049(93)90303-w
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发表时间：
1993-01-01
影响因子：
8.4
通讯作者：
DAVARIS, P
中科院分区：
文献类型：
--
作者：
NAKOPOULOU, L;JANINIS, J;DAVARIS, P
增殖细胞核抗原/细胞周期蛋白被认为是细胞增殖的标志。本研究的目的是探讨上皮性卵巢肿瘤(EON)中增殖细胞核抗原/细胞周期蛋白的表达及其与肿瘤分化程度、肿瘤分期和总生存期的关系。其中良性EON 34例，恶性EON 40例。良性组2/34(6%)，恶性组23/39(59%)(P<；0.001)。高增殖组临床诊断多为晚期。增殖细胞核抗原阳性组与阴性组、高增殖组与低增殖组的总生存率差异无统计学意义。综上所述，增殖细胞核抗原作为EON恶性潜能和预后指标的作用值得进一步研究。
Proliferating cell nuclear antigen (PCNA)/cyclin is considered to be a marker of cell proliferation. The aim of this study was to evaluate the expression of PCNA/cyclin in epithelial ovarian neoplasms (EON) as well as the possible correlation with degree of differentiation, tumour stage and overall survival. The material consisted of 34 benign and 40 malignant EON. Positive nuclear staining was detected in 2/34 (6%) of benign and 23/39 (59%) malignant EON (P < 0.001). Most cases in the high proliferation group were diagnosed in advanced clinical stages. There was no difference in overall survival between nuclear PCNA positive and negative patients, as well as the high and the low proliferation group. In conclusion, the role of PCNA as a marker of malignant potential and prognosis in EON merits further investigation.