Quantitative Risk Estimation for Large for Gestational Age Using the Area Under the 100-g Oral Glucose Tolerance Test Curve
Quantitative Risk Estimation for Large for Gestational Age Using the Area Under the 100-g Oral Glucose Tolerance Test Curve
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DOI：
10.1002/jcla.20326
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发表时间：
2009-01-01
影响因子：
2.7
通讯作者：
Kim, Ahm
中科院分区：
文献类型：
--
作者：
Kim, Sollip;Min, Won-Ki;Kim, Ahm
我们设计了一种补充的定量方法，用于妊娠期糖尿病（GDM），使用口服葡萄糖耐量试验（OGTT）结果的曲线下面积（AUC），并评估其在预测新生儿将大于胎龄（LGA）的有效性。研究对象为648名孕妇。根据100-g OGTT结果计算AUC-OGTT（浓度×时间）。根据AUC-OGTT的每个范围估计LGA的发生率，并使用多元Logistic回归分析分析比值比。LGA的发生率随着AUC-OGTT值的增加而增加，AUC= 600时为0%。LGA的比值比增加约2倍，AUC-OGTT增加100。结果表明，AUC-OGTT可用于GDM患者LGA的危险性评估。AUC-OGTT可作为GDM常规诊断标准的补充。J. Clin. Lab. Anal. 23：231-236，2009. (C)2009威利-利斯公司
We devised a complementary quantitative method for gestational diabetes (GDM) that uses the area under the curve (AUC) of the results of the oral glucose tolerance test (OGTT), and evaluated its efficacy in predicting neonates that would be large for gestational age (LGA). The study subjects were 648 pregnant women. The AUC-OGTT (concentration x time) was calculated from the 100-g OGTT results. The incidence of LGA according to each range of the AUC-OGTT was estimated and odds ratios were analyzed using multiple logistic regression analysis. The incidence of LGA increased with the AUC-OGTT value and was 0% for AUC= 600. The odds ratio of LGA increased by approximately two-fold with an increase of 100 in the AUC-OGTT. The results indicated that the AUC-OGTT can be used to quantify the risk of LGA in GDM. The AUC-OGTT could complement a diagnosis of GDM using conventional diagnostic criteria. J. Clin. Lab. Anal. 23:231-236, 2009. (C) 2009 Wiley-Liss, Inc.