Solubility determination and thermodynamic modelling of gliclazide in five binary solvent mixtures
Solubility determination and thermodynamic modelling of gliclazide in five binary solvent mixtures
复制标题
格列齐特在五种二元溶剂混合物中的溶解度测定和热力学建模
DOI：
10.1016/j.molliq.2020.113258
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发表时间：
2020-08-01
影响因子：
6
通讯作者：
Xue, Fumin
中科院分区：
文献类型：
--
作者：
Yu, Shuai;Cheng, Yan;Xue, Fumin
采用重量法测定了格列齐特在丙酮-水、四氢呋喃-水、N，N-二甲基甲酰胺-水、丙酮-乙醇和氯仿-乙醇五种二元混合溶剂中的溶解度。结果表明，格列齐特的溶解度随温度的升高和非极性非质子溶剂摩尔分数的增加而增加。选择组合近理想溶剂/ Redlish-Kister（CNIBS/R-K）模型、修正的Jouyban-Acree模型、非随机双液（NRTL）模型和Wilson模型来校正溶解度数据。结果表明，溶剂极性对格列齐特的溶解度有重要影响。CNIBS/R-K模型的最大RAD和RMSD值分别为0.0540和0.000131，被发现是所选二元溶剂混合物中溶解度数据校正的最佳拟合模型。所有选定的热力学模型的RAD值为
The solubility of gliclazide in five different binary solvent mixtures, (i.e. acetone-water, tetrahydrofuran-water, N, N-dimethylformamide-water, acetone-ethanol, and chloroform-ethanol) was measured in the temperature rang 278.15-318.15 K and at atmospheric pressure by a gravimetric method. The results show that the solubility of gliclazide increases with an increase in temperature and an increase in the mole fraction of nonpolar aprotic solvent. The combined nearly ideal solvent / Redlish-Kister (CNIBS/R-K) model, modified Jouyban-Acree model, non-random two-liquid (NRTL) model, and the Wilson model were selected to correct the solubility data. It was found that, solvent polarity has a critical effect on the solubility of gliclazide. The CNIBS/R-K model, with maximum RAD and RMSD values of 0.0540 and 0.000131, respectively, was found to be the best-fitting model for solubility data correction in the selected binary solvent mixtures. RAD values of all the selected thermodynamic models were