Focal epileptiform activity described by a large computerised EEG database
Focal epileptiform activity described by a large computerised EEG database
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DOI：
10.1016/j.clinph.2007.02.027
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发表时间：
2007-06-01
影响因子：
4.7
通讯作者：
Gilhus, N. E.
中科院分区：
文献类型：
--
作者：
Aurlien, H.;Aarseth, J. H.;Gilhus, N. E.
目的：研究癫痫样活动的年龄相关的地形倾向，以及局灶性癫痫样活动（FEA）对一般皮层脑activity.Methods的影响：1647个连续的常规脑电图包含FEA进行了视觉评估FEA的位置和不对称性。背景活动进行了比较，在正常脑电图从3268无药门诊controls.Results：FEA本地化是年龄相关的（p < 0.0005），除了颞区（p = 0.22），FEA被发现同样经常在年轻人和老年人。左半球更容易发生FEA（p = 0.018）。左右不对称随年龄而变化（p = 0.013）。FEA不对称最常发生在80岁以上患者的EEG中，最不常见于20-39岁年龄组。FEA与较低的α节律（AR）频率（p = 0.0041）和较高的AR振幅（p = 0.0023）以及较高的一般背景活动（GBA）振幅（p < 0.0005）相关，而GBA频率相同（p = 0.96）。结论：FEA的地形定位与年龄有关。有一个整体的左优势，但侧不对称是适度的，并随年龄而变化。FEA与AR和GBA的变化相关。意义：结果表明FEA与远离癫痫灶的大脑皮质功能障碍有关。(C)2007年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To study the age-related topographical tendency of expressing epileptiform activity, and the effect of focal epileptiform activity (FEA) on the general cortical brain activity.Methods: 1647 consecutive routine EEGs containing FEA were visually assessed for FEA location and asymmetry. Background activity was compared with that in normal EEGs from 3268 drug-free outpatient controls.Results: FEA localisation was age-related (p < 0.0005) except for the temporal region (p = 0.22) where FEA was found equally often in the young and the old. The left hemisphere was more prone to FEA (p = 0.018). The left right asymmetry varied by age (p = 0.013). FEA asymmetry occurred most frequently in EEGs from patients older than 80 years, and least frequent in the age-group 20-39 years. FEA was associated with lower alpha rhythm (AR) frequencies (p = 0.0041) and higher AR amplitudes (p = 0.0023), as well as higher general background activity (GBA) amplitude (p < 0.0005), while GBA frequencies were the same (p = 0.96).Conclusions: Topographical localisation of FEA was age-dependent. There was an overall left dominance, but the side asymmetry was modest and varied by age. FEA was associated with changes in AR and GBA.Significance: The results demonstrate that FEA is associated with cerebral cortical dysfunction also distant from the epileptic focus. (C) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.