Dietary lutein/zeaxanthin decreases ultraviolet B-induced epidermal hyperproliferation and acute inflammation in hairless mice
Dietary lutein/zeaxanthin decreases ultraviolet B-induced epidermal hyperproliferation and acute inflammation in hairless mice
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DOI：
10.1046/j.1523-1747.2003.12355.x
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发表时间：
2003-08-01
影响因子：
6.5
通讯作者：
Pathak, MA
中科院分区：
文献类型：
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作者：
González, S;Astner, S;Pathak, MA
叶黄素和玉米黄质是在绿色叶菜中发现的类胡萝卜素，具有有趣的抗氧化特性。它们以高浓度存在于人视网膜的中央凹中，并且已经报道了它们在预防年龄相关性黄斑变性中的作用。我们研究了口服叶黄素和玉米黄质对紫外线B照射皮肤反应的影响。雌性无毛SKh-1小鼠接受0.4%和0.04%叶黄素加玉米黄质强化饲料2周暴露于单剂量的紫外线B辐射。在照射后24和48 h取皮肤活检，并分析凋亡细胞、增殖细胞和增殖细胞核抗原表达的存在。我们的研究结果表明，一个明确的紫外线诱导的剂量依赖性炎症反应。口服0.4%叶黄素和玉米黄质可显著降低皮肤水肿反应（p
Lutein and zeaxanthin are carotenoids found in green leafy vegetables with interesting antioxidant properties. They are present in high concentrations in the fovea centralis of the human retina and their role in the prevention of age-related macula degeneration has been reported. We have investigated the effect of orally administered lutein and zeaxanthin in the cutaneous response to ultraviolet B irradiation. Female hairless SKh-1 mice receiving 0.4% and 0.04% lutein plus zeaxanthin-enriched diet for 2 wk were exposed to single doses of ultraviolet B radiation. Skin biopsies were taken at 24 and 48 h after irradiation and analyzed for the presence of apoptotic cells, proliferating cells, and expression of proliferating cell nuclear antigen. Our results show a clear ultraviolet-induced dose-dependent inflammatory response. Orally administered 0.4% lutein and zeaxanthin decreased significantly the edematous cutaneous response (p