Virulence factors and strategies of Leptopilina spp.: selective responses in Drosophila hosts.
Virulence factors and strategies of Leptopilina spp.: selective responses in Drosophila hosts.
复制标题
DOI：
10.1016/s0065-308x(09)70005-3
复制
发表时间：
2009
影响因子：
--
通讯作者：
Govind, Shubha
中科院分区：
文献类型：
--
作者：
Lee, Mark J.;Kalamarz, Marta E.;Paddibhatla, Indira;Small, Chiyedza;Rajwani, Roma;Govind, Shubha
为了确保生存，果蝇的寄生蜂已经进化出优化宿主发育的策略。它们还产生毒力因子，使它们能够克服或逃避宿主防御。黄蜂感染引起细胞和体液防御反应，导致宿主基因表达的改变。这些反应的激活由其他无脊椎动物和脊椎动物共有的保守机制控制。基因组学和生物信息学方法的应用开始揭示不同寄生蜂感染后宿主基因表达的比较变化。我们分析了这种比较的背景下，宿主生理和免疫细胞，以及生物学的毒液因子，黄蜂介绍到他们的主机在产卵。本文比较了鲍氏细青霉和L.异源瘤，与感染后果蝇宿主基因表达的全基因组变化有关。这种分析突出了根本的差异，主机在其免疫和一般生理学的变化，在响应两个寄生蜂。这种比较方法有可能揭示致病性的演变机制，以及它如何影响宿主范围。
To ensure survival, parasitic wasps of Drosophila have evolved strategies to optimize host development to their advantage. They also produce virulence factors that allow them to overcome or evade host defense. Wasp infection provokes cellular and humoral defense reactions, resulting in alteration in gene expression of the host. The activation of these reactions is controlled by conserved mechanisms shared by other invertebrate and vertebrate animals. Application of genomics and bioinformatics approaches is beginning to reveal comparative host gene expression changes after infection by different parasitic wasps. We analyze this comparison in the context of host physiology and immune cells, as well as the biology of the venom factors that wasps introduce into their hosts during oviposition. We compare virulence strategies of Leptopilina boulardi and L. heterotoma, in relation to genome-wide changes in gene expression in the fly hosts after infection. This analysis highlights fundamental differences in the changes that the host undergoes in its immune and general physiology in response to the two parasitic wasps. Such a comparative approach has the potential of revealing mechanisms governing the evolution of pathogenicity and how it impacts host range.