Modular Architectonic Organization of the Insula in the Macaque Monkey
Modular Architectonic Organization of the Insula in the Macaque Monkey
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DOI：
10.1002/cne.23436
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发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Craig, A. D. (Bud)
中科院分区：
文献类型：
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作者：
Evrard, Henry C.;Logothetis, Nikos K.;Craig, A. D. (Bud)
为了给使用现代高分辨率方法分析猕猴岛叶皮质神经元连接提供一个框架，我们用Nissl和Galyas(髓鞘)技术交替染色的连续冠状切片观察了它的解剖组织。我们在10个大脑中观察了相同的15个不同的建筑区域。在先前研究中描述的颗粒区、非颗粒区和无颗粒区中，我们分别确定了4、4和7个不同的区域。在整个大脑中，这些区域具有一致的建筑特征，在平面地图重建中，它们显示出一致的拓扑或邻域排列，尽管不同情况下单个区域的大小有所不同。地区之间的边界通常是相当明确的。一些区域，特别是非颗粒区，似乎始终包含微妙的过渡，这表明在划分良好的区域内可能存在分区或模块。横跨上限沟从后到前的整个范围的明显颗粒区的存在与丘脑感觉间投射的现有证据一致，也与物种特异性皮质回旋的张力锚理论相一致。这些观察结果与灵长类脑岛的动态平衡传入加工模型是一致的，它们表明岛叶皮质内的离散模块为其与正在进行的情绪行为相关的所有显著活动的多模式整合提供了基础。J.Comp.神经。2014年，以97胜97负。(C)2013年威利期刊公司。
In order to provide a framework for ongoing analyses of the neuronal connections of the insular cortex of the macaque monkey using modern high-resolution methods, we examined its anatomical organization in serial coronal sections stained alternately with Nissl and Gallyas (myelin) techniques. We observed the same 15 distinct architectonic areas in 10 brains. Within the granular, dysgranular, and agranular regions described in prior studies, we identified 4, 4, and 7 distinct areas, respectively. Across brains, these areas have consistent architectonic characteristics, and in flat map reconstructions they display a consistent topological or neighborhood arrangement, despite variations in the size of individual areas between cases. The borders between areas are generally rather sharply defined. Some areas, in particular the dysgranular areas, appear to consistently contain subtle transitions that suggest possible subareas or modules within the well-delimited areas. The presence of a distinct granular area that straddles the fundus of the superior limiting sulcus over its entire posterior-to-anterior extent is consistent with the available evidence on interoceptive thalamocortical projections, and also with the tensile anchor theory of species-specific cortical gyrification. These observations are consonant with the model of homeostatic afferent processing in the primate insula, and they suggest that discrete modules within insular cortex provide the basis for its polymodal integration of all salient activity relevant to ongoing emotional behavior. J. Comp. Neurol. 522:64-97, 2014. (c) 2013 Wiley Periodicals, Inc.