HLAMatchmaker-defined triplet matching is not associated with better survival rates of patients with class I HLA allele mismatched hematopoietic cell transplants from unrelated donors.
HLAMatchmaker-defined triplet matching is not associated with better survival rates of patients with class I HLA allele mismatched hematopoietic cell transplants from unrelated donors.
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HlamatchMatchMaker定义的三重匹配匹配与I级HLA等位基因不匹配的造血细胞移植的患者的生存率更好。
DOI：
10.1016/j.bbmt.2008.07.001
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发表时间：
2008-09
影响因子：
4.3
通讯作者：
Oudsboorn, Machteld
中科院分区：
文献类型：
--
作者：
Duquesnoy, Rene;Spellman, Stephen;Haagenson, Michael;Wang, Tao;Horowitz, Mary M.;Oudsboorn, Machteld
本报告阐述了造血干细胞移植（HCT）中允许的HLA错配（即不产生同种异体反应的错配）可以通过多态性区域的结构相似性来确定的概念。我们已经应用了三联体版本的结构算法称为HLAMatchmaker，认为短序列涉及多态性氨基酸残基的分子表面作为免疫原性表位的关键要素。在由744例具有一个HLA-A、-B或-C错配的无关造血细胞移植病例和1690例完全HLA-A、-B、-C、-DR、-DQ等位基因匹配的病例组成的国家骨髓供体计划数据集中分析三联体匹配效应。在调整其他重要临床风险因素的多变量模型中，三联体错配的程度与患者生存率、植入或急性移植物抗宿主病无显著相关性。其他基于结构的策略，应追求，以确定允许的HLA错配HCT。
This report addresses the concept that permissible HLA mismatching, i.e. mismatches that do not generate an allogeneic response, in hematopoietic stem cell transplantation (HCT) can be determined with structural similarity of polymorphic regions. We have applied the triplet version of a structural algorithm called HLAMatchmaker that considers short sequences involving polymorphic amino acid residues on the molecular surface as key elements of immunogenic epitopes. The triplet matching effect was analyzed in a National Marrow Donor Program dataset consisting of 744 unrelated hematopoietic cell transplantation cases with one HLA-A,-B or -C mismatch and 1690 fully HLA-A,-B,-C,-DR,-DQ allele matched cases. In multivariate models adjusting for other significant clinical risk factors, the degree of triplet mismatching did not significantly correlate with patient survival, engraftment or acute graft versus host disease. Other structurally based strategies should be pursued to identify permissible HLA mismatches in HCT.
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影响因子：
4.4
作者：
Doytchinova, IA;Guan, PP;Flower, DR
通讯作者：
Flower, DR
影响因子：
20.3
作者：
Kawase, Takakazu;Morishima, Yasuo;Sasazuki, Takehiko
通讯作者：
Sasazuki, Takehiko
影响因子：
6.2
作者：
Böhringer, D;Reinhard, T;Sundmacher, R
通讯作者：
Sundmacher, R
影响因子：
20.3
作者：
Ferrara, GB;Bacigalupo, A;Frumento, G
通讯作者：
Frumento, G
影响因子：
--
作者：
Petersdorf, E. W.;Gooley, T.;Horowitz, M.
通讯作者：
Horowitz, M.