Calorie restriction in rhesus monkeys
Calorie restriction in rhesus monkeys
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DOI：
10.1016/s0531-5565(02)00146-8
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发表时间：
2003-01-01
影响因子：
3.9
通讯作者：
Ingram, DK
中科院分区：
文献类型：
--
作者：
Mattison, JA;Lane, MA;Ingram, DK
在一些动物模型中，卡路里限制（CR）延长了寿命，降低了年龄相关疾病的发病率和发病年龄。为了确定这种营养干预是否对长寿的灵长类动物有类似的作用，美国国家衰老研究所（NIA）于1987年启动了一项研究，调查30% CR对不同年龄范围的雄性和雌性恒河猴（Macaca mulatta）的影响。我们已经观察到CR对啮齿动物的生理影响，并可能预测寿命的延长。具体来说，NIA的研究结果表明，CR可以降低体重和脂肪量，改善血糖调节功能，降低血压和血脂，降低体温。幼年雄性表现出骨骼和性成熟的延迟。女性成年骨量不受CR的影响，也不受几种生殖激素或月经周期的影响。CR减轻了男性脱氢表雄酮（DHEA）和褪黑激素与年龄相关的下降。虽然研究中81%的猴子仍然活着，但初步证据表明，CR将对发病率和死亡率产生有益的影响。我们现在正在准备一系列措施，对CR在延缓与年龄有关的疾病的发病和维持晚年功能方面的有效性进行全面和相关的分析。(C) 2002爱思唯尔科学有限公司版权所有。
Calorie restriction (CR) extends lifespan and reduces the incidence and age of onset of age-related disease in several animal models. To determine if this nutritional intervention has similar actions in a long-lived primate species, the National Institute on Aging (NIA) initiated a study in 1987 to investigate the effects of a 30% CR in male and female rhesus macaques (Macaca mulatta) of a broad age range. We have observed physiological effects of CR that parallel rodent studies and may be predictive of an increased lifespan. Specifically, results from the NIA study have demonstrated that CR decreases body weight and fat mass, improves glucoregulatory function, decreases blood pressure and blood lipids, and decreases body temperature. Juvenile males exhibited delayed skeletal and sexual maturation. Adult bone mass was not affected by CR in females nor were several reproductive hormones or menstrual cycling. CR attenuated the age-associated decline in both dehydroepiandrosterone (DHEA) and melatonin in males. Although 81% of the monkeys in the study are still alive, preliminary evidence suggests that CR will have beneficial effects on morbidity and mortality. We are now preparing a battery of measures to provide a thorough and relevant analysis of the effectiveness of CR at delaying the onset of age-related disease and maintaining function later into life. (C) 2002 Elsevier Science Inc. All rights reserved.