Transcranial Magnetic Stimulation-induced Changes in Scalp-recorded EEG and Evoked Responses in Patients with Cerebrovascular Disease
Transcranial Magnetic Stimulation-induced Changes in Scalp-recorded EEG and Evoked Responses in Patients with Cerebrovascular Disease
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经颅磁刺激引起脑血管疾病患者头皮记录脑电图和诱发反应的变化
DOI：
10.2490/jjrm1963.35.738
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
A. Ishida
中科院分区：
文献类型：
--
作者：
S. Izumi;M. Takase;N. Chino;Motohide Arita;A. Ishida
我们评估了4例中风患者的头皮记录脑电(EEG)和经颅磁刺激(TMS)诱发反应的变化。圆形线圈的中心位于顶点。每隔3~5s顺时针刺激40次，输出电流最大。使用在刺激后阻断输入150毫秒的电路来减少刺激伪影。从F3/4、C3/4、P3/4和T3/4记录脑电。每次刺激后立即观察到脑电减慢(150毫秒)。改变的发生率从10%到80%不等，改变的持续时间从250到600毫秒不等。与轻中度偏瘫或脑桥病变的患者相比，接受抗惊厥药物治疗的皮质下大型病变的密集偏瘫患者的基线脑电异常，脑电变化的发生率较低。在1例腔隙性脑梗塞致轻度偏瘫患者中，TMS诱发的脑电反应平均为温和的正波，融合有1~3个负峰。这项研究中使用的方法可能有助于评估中风患者对TMS的敏感性。
We evaluated changes in the scalp-recorded electroencephalogram (EEG) and evoked responses induced by transcranial magnetic stimulation (TMS) in four stroke patients. The center of a circular coil was positioned at the vertex. Forty clockwise stimulations were administered every 3-5 sec with the maximum output of electric current. A circuit that blocked the input for 150 msec after stimulation was used to reduce stimulus artifact. EEGs were recorded from F3/4, C3/4, P3/4, and T3/4. Slowing of the EEG was observed immediately (150 msec) after each stimulation. The incidence of changes ranged from 10 to 80% and the duration of the change ranged from 250 to 600 msec. A densely hemiplegic patient with a large subcortical lesion who was taking anticonvulsant medication had an abnormal baseline EEG and showed a lower incidence of EEG changes compared to patients with mild to moderate hemiplegia or pontine lesions. In a patient with mild hemiplegia due to a lacunar infarction, averaged TMS-evoked electroencephalographic responses appeared as gentle positive waves, fused with 1 to 3 negative peaks. The methods used in this study may be useful in evaluating the sensitivity of stroke patients to TMS.