Mapping sequence structure in the human lateral entorhinal cortex
Mapping sequence structure in the human lateral entorhinal cortex
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DOI：
10.7554/elife.45333
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发表时间：
2019-08-06
期刊：
影响因子：
7.7
通讯作者：
Doeller, Christian F.
中科院分区：
文献类型：
--
作者：
Bellmund, Jacob L. S.;Deuker, Lorena;Doeller, Christian F.
记住事件序列是情景记忆的核心，并且可能受到海马内嗅区的支持。我们之前证明，海马体映射了虚拟城市沿线遇到的事件之间的空间和时间距离（Deuker et al., 2016），但内嗅助记表征的内容仍不清楚。在这里，我们证明了前外侧内嗅皮层（alEC）（啮齿动物外侧内嗅皮层的人类同源物）中的多体素表示特别反映了学习后的时间事件结构。与记忆回忆和事件时间线相关的序列结构的整体表示可以从内嗅多体素模式重建。我们的研究结果证明了 alEC 中时间结构的表征；与导航啮齿类动物外侧内嗅皮层中的群体信号所携带的时间信息以及时间记忆检索过程中的 aEC 激活相吻合。我们的结果为 aEC 在代表情景记忆时间方面的作用提供了新的证据。
Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through a virtual city (Deuker et al., 2016), but the content of entorhinal mnemonic representations remains unclear. Here, we demonstrate that multi-voxel representations in the anterior-lateral entorhinal cortex (alEC) - the human homologue of the rodent lateral entorhinal cortex - specifically reflect the temporal event structure after learning. Holistic representations of the sequence structure related to memory recall and the timeline of events could be reconstructed from entorhinal multi-voxel patterns. Our findings demonstrate representations of temporal structure in the alEC; dovetailing with temporal information carried by population signals in the lateral entorhinal cortex of navigating rodents and alEC activations during temporal memory retrieval. Our results provide novel evidence for the role of the alEC in representing time for episodic memory.