OUTBREAK OF ACUTE HEPATITIS-E VIRUS-INFECTION AMONG MILITARY PERSONNEL IN NORTHERN ETHIOPIA
OUTBREAK OF ACUTE HEPATITIS-E VIRUS-INFECTION AMONG MILITARY PERSONNEL IN NORTHERN ETHIOPIA
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DOI：
10.1002/jmv.1890340407
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发表时间：
1991-08-01
影响因子：
12.7
通讯作者：
BAHRU, Y
中科院分区：
文献类型：
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作者：
TSEGA, E;KRAWCZYNSKI, K;BAHRU, Y
1988年10月至1989年3月，埃塞俄比亚北部军营爆发了急性戊型肝炎病毒（HEV）感染。这种流行病是水传播的，完全局限于军人，对其中423名住院的黄疸患者进行了研究。临床病程轻而短，无暴发性肝炎及死亡。所有抗hav -IgM血清检测均为阴性，在54例（13%）HBsAg阳性患者中，7例（2%）抗hbc IgM阳性。另一方面，30例患者中有28例（93%）有戊型肝炎病毒抗体，而29例无症状对照组中有1例（3%）有戊型肝炎病毒抗体（P < 0.01）。强调需要有一种容易获得、价格低廉的HEV感染血清学检测方法，保护供水不受粪便污染，对饮用水进行适当的氯化和/或煮沸，以及关于个人和环境卫生的健康教育，特别是在高危社区。
An outbreak of acute hepatitis E virus (HEV) infection occurred from October 1988 to March 1989 in military camps in northern Ethiopia. The epidemic was waterborne and entirely confined to military men, of whom 423 hospitalized, icteric patients were studied. The clinical course was mild and short, without any fulminant hepatitis or death. All sera tested for anti-HAV-IgM were negative and among 54 (13%) patients who were positive for HBsAg, 7 (2%) were positive for anti-HBc IgM. On the other hand, 28 of 30 (93%) patients had antibodies against hepatitis E virus (anti-HEV) in contrast to 1 of 29 (3%) asymptomatic controls (P < .01). The need for an easily available, inexpensive serologic test for HEV infection, protection of water supplies from fecal contamination, adequate chlorination and/or boiling of drinking water, and health education about personal and environmental hygiene, especially in communities at high risk, is emphasized.