Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease
Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease
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DOI：
10.1016/j.alcohol.2004.08.005
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发表时间：
2004-08-01
期刊：
影响因子：
2.3
通讯作者：
Nanji, AA
中科院分区：
文献类型：
--
作者：
Nanji, AA
膳食脂肪酸和酒精在酒精性肝病的发病机制中都发挥着重要作用。对大鼠的研究结果表明膳食脂肪具有致脂肪作用。研究结果支持了多不饱和脂肪酸在酒精性肝病中的作用，该研究表明病理变化仅发生在喂食含有多不饱和脂肪酸的乙醇的大鼠中。脂肪酸促进酒精性肝病的机制包括氧化应激增强、内毒素产生和促炎细胞因子表达增加。 (C) 2005 Elsevier Inc. 保留所有权利。
Both dietary fatty acids and alcohol play an important role in the pathogenesis of alcoholic liver disease. Findings of studies in rats show a steatogenic role for dietary fat. A role for polyunsaturated fatty acids in alcoholic liver disease is supported by results of studies, which show that pathologic changes occur only in rats fed ethanol with polyunsaturated fatty acids. The mechanisms through which the fatty acids promote alcoholic liver disease include enhanced oxidative stress, production of endotoxin, and increased expression of proinflammatory cytokines. (C) 2005 Elsevier Inc. All rights reserved.