A Follow-Up Study on the Clinical Outcomes of Alveolar Reconstruction Using Octacalcium Phosphate Granules and Atelocollagen Complex
A Follow-Up Study on the Clinical Outcomes of Alveolar Reconstruction Using Octacalcium Phosphate Granules and Atelocollagen Complex
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DOI：
10.1016/j.joms.2021.09.017
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发表时间：
2021-11-30
影响因子：
1.9
通讯作者：
Nakamura, Norifumi
中科院分区：
文献类型：
--
作者：
Kibe, Toshiro;Maeda-Iino, Aya;Nakamura, Norifumi
目的：目的观察磷酸八钙颗粒和端胶原复合物（OCP/Col）修复单侧唇裂伴腭裂（UCL +/- P）患者牙槽突裂术后远期成骨情况及邻牙萌出情况。研究方法：4例接受OCP/Col移植的UCL +/- P患者（OCP组）和55例接受自体骨移植的UCL +/- P患者（AB组）入组本研究。在替牙期尖牙或侧切牙萌出前进行OCP/Col或自体骨移植，然后进行正畸治疗。OCP组患者在术前和术后1、2、3、6和30个月以上接受X线摄影。术后6个月比较OCP组和AB组牙槽突裂区骨缺损的体积和面积。结果如下：OCP/Col组所有患者的骨桥均成功形成，术后6个月，邻近牙槽突裂的恒牙已在OCP/Col复合移植物部位萌出。两组术前术后骨缺损的比较显示，骨桥形成的程度几乎相同。结论：OCP/Col移植可被认为是自体骨移植的替代方法，因为它产生了成功的骨桥形成并促进恒牙萌出。(c)2021作者爱思唯尔公司出版代表美国口腔颌面外科医师协会。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。口腔颌面外科杂志79：2462-2471，2021
Purpose: To observe the long-term postoperative bone formation and eruption of adjacent teeth after octacalcium phosphate granule and atelocollagen complex (OCP/Col) grafting in the treatment of alveolar cleft of patients with unilateral cleft lip with or without cleft palate (UCL +/- P). Methods: Four patients with UCL +/- P who underwent OCP/Col grafting (OCP group), and 55 patients with UCL +/- P who underwent autologous bone grafting (AB group) were enrolled in this study. OCP/Col or autologous bone grafting was performed before the eruption of canines or lateral incisors in mixed dentition, followed by orthodontic management. Patients in the OCP group underwent radiography before and after surgery at 1, 2, 3, 6, and over 30 months postoperatively. The volume and area of the bony defect in the alveolar cleft area were compared between the OCP and AB groups before and after 6 months of surgery. Results: The bone bridge in all patients in the OCP/Col group was successfully formed, and by 6 months postoperatively, the permanent teeth adjacent to the alveolar cleft had erupted at the site of the OCP/Col complex graft. Comparison of the pre- and postoperative bone defects between the 2 groups revealed almost the same extent of bone bridge formation. Conclusions: OCP/Col grafting could be considered as an alternative to autologous bone grafting as it yielded successful bone bridge formation and facilitated permanent tooth eruption. (c) 2021 The Author. Published by Elsevier Inc. on behalf of The American Association of Oral and Maxillofacial Surgeons. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). J Oral Maxillofac Surg 79:2462-2471, 2021