MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors
MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors
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DOI：
10.1186/s13048-018-0416-x
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发表时间：
2018-06-05
影响因子：
4
通讯作者：
Zhang, Guofu
中科院分区：
文献类型：
--
作者：
Zhang, He;Zhang, Hongyu;Zhang, Guofu
背景资料：目的：探讨卵巢颗粒细胞瘤（OGCTs）的MRI表现，并与卵巢其他性索间质肿瘤（OSCs）进行比较。所有MR检查均在一个月内前瞻性进行。结果：18例患者中，MRI共检出20个卵巢颗粒细胞瘤，其中卵巢颗粒细胞瘤10例，卵巢颗粒细胞瘤10例，卵巢颗粒细胞瘤10例，卵巢颗粒细胞瘤10例。16例为实性或多为实性肿块（16/20），4例为囊性肿块。1例OGCT（1/18）和11例OSCs（11/34）检出病理性盆腔积液在T2 WI上，多数OGCT呈高信号或混杂信号（19/20）;在T1加权成像（T1 WI）上，11例（11/20）OGCT在T_2 WI上显示与OSC相似的信号，OGCT与OSC在T_1 WI上的信号有显著性差异（p = 0.017）和T2 WI（p = 0.002）。MRI检查发现6例OGCT有肿瘤出血。在扩散加权成像（DWI）上，OGCT多呈高信号（16/20）。OGCT组DWI图像的平均表观扩散系数（ADC）值（0.84 ± 0.26 × 10（-3）mm（2）/s）小于对照组（1.22 ± 0.47 × 10（-3）mm（2）/s），差异有统计学意义（p = 0.002）。ADC值对OGCT和OSC的鉴别诊断有一定的参考价值。
Background: To describe magnetic resonance imaging (MRI) features of ovarian granulosa cell tumors (OGCTs) and compare with othei sex cord-stromal tumors (OSCs) in ovary.Methods: MR findings of 18 patients with surgically confirmed ovarian granulosa cell tumor were retrospectively reviewed by two radiologists with consensus reading. All MR examinations were prospectively performed within one month. Clinical and imaging characteristics of OGCTs were evaluated and compared with OSCs (control group).Results: In 18 patients, 20 ovarian granulosa cell tumors were detected on MRI. Sixteen tumors appeared as solid or mostly solid mass (16/20), while 4 tumors as cystic mass. Pathological pelvic fluid was detected in 1 OGCT (1/18) and 11 OSCs (11/34) (p = 0.031).On T2 weighted imaging (T2WI), most of OGCTs displayed hyperintense signal and mixed signal (19/20); on T1 weighted imaging (T1WI), 11 OGCTs (11/20) displayed similar signal as on T2WI imaging The lesion signal between OGCT and OSC differed significantly on both T1WI (p = 0.017) and T2WI (p = 0.002). Tumoral bleeding was detected in 6 OGCTs on MRI. On diffusion weighted imaging (DWI) images, OGCTs mostly appeared as high signal (16/20). Average apparent diffusion coefficient (ADC) value derived from DWI images in the OGCT group (0.84 +/- 0.26x10(-3) mm(2)/s was less than the control group (1.22 +/- 0.47 x 10(-3) mm(2)/s) with statistical difference (p = 0.002).Conclusions: MRI could provide important information in OGCT diagnosis. ADC value might be useful in differentiating OGCT from OSC.