A census of human cancer genes.
A census of human cancer genes.
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DOI：
10.1038/nrc1299
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发表时间：
2004-03
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癌症研究的一个中心目标是确定与肿瘤发生有因果关系的突变基因（“癌症基因”）。经过20年的搜索，有多少已经被确定，它们如何与人类基因组序列所揭示的完整基因集进行比较？我们对癌症基因进行了一次“普查”，结果表明超过1%的基因突变会导致人类癌症。这次普查显示了序列改变类型、已发现致癌突变的癌症类别以及由癌症基因编码的蛋白质结构域的显著特征。
A central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis (‘cancer genes’). After two decades of searching, how many have been identified and how do they compare to the complete gene set that has been revealed by the human genome sequence? We have conducted a ‘census’ of cancer genes that indicates that mutations in more than 1% of genes contribute to human cancer. The census illustrates striking features in the types of sequence alteration, cancer classes in which oncogenic mutations have been identified and protein domains that are encoded by cancer genes.