The marginal layer in the neocortex of a 7 week-old human embryo
The marginal layer in the neocortex of a 7 week-old human embryo
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DOI：
10.1007/bf00299974
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发表时间：
1981-08
期刊：
影响因子：
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通讯作者：
J. Larroche
中科院分区：
文献类型：
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作者：
J. Larroche
7周大的人类胚胎新皮层分子层的超微结构研究证实了最近在各种实验动物上的观察，这些观察要求修订一些经典的皮质发生概念。7周时，脑膜下层、边缘层或分子层是第一个与脑室层区分的层，几乎占脑端囊厚度的一半。第一批已经从心室区迁移的细胞，甚至在任何皮质板可见之前，就在这个边缘层中被发现。这些大细胞分化良好，很可能代表所谓的Cajal Retzius细胞。在人类胚胎中发现的最早的突触位于边缘层或丛状层；这表明在这一水平上存在一个复杂的神经回路的早熟设置。
Ultrastructural study of the molecular layer of the neocortex of a 7 week-old human embryo confirms recent observations on various laboratory animals that call for revision of some classical concepts of corticogenesis.1.At 7 weeks, the subpial, marginal or molecular layer is the first layer to differentiate from the ventricular layer and represents almost half the thickness of the telencephalic vesicle.2.The first cells that have already migrated from the ventricular zone, even before any cortical plate is visible, are to be found in this marginal layer. These large cells are well differentiated and most probably represent the so called Cajal Retzius cells.3.The earliest synapses ever seen in human embryol are found in the marginal or plexiform layer; this indicates the presence of a precocious set-up for an elaborate neuronal circuitry at this level.