Accelerated apoptosis in SLE neutrophils cultured with anti-dsDNA antibody isolated from SLE patient serum: a pilot study
Accelerated apoptosis in SLE neutrophils cultured with anti-dsDNA antibody isolated from SLE patient serum: a pilot study
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DOI：
10.1007/s00296-006-0219-z
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发表时间：
2006-12-01
影响因子：
4
通讯作者：
Bell, Aubrey L.
中科院分区：
文献类型：
--
作者：
Armstrong, David J.;Crockard, Alistair D.;Bell, Aubrey L.
SLE患者中性粒细胞凋亡数量增加，与疾病活动性和抗dsDNA抗体水平有关。细胞凋亡增加的机制尚不清楚，但抗dsDNA抗体已显示在正常受试者的中性粒细胞和某些细胞系中诱导细胞凋亡。在这项研究中，多克隆抗dsDNA抗体分离自患有活动性SLE的患者的血清，并且显示与来自健康对照或类风湿性关节炎受试者的中性粒细胞相比，显著加速来自SLE患者的中性粒细胞的凋亡。
Increased numbers of apoptotic neutrophils are found in SLE, related to disease activity and levels of anti-dsDNA antibody. The mechanism of increased apoptosis is not clear, but anti-dsDNA antibody has been shown to induce apoptosis in neutrophils from normal subjects and in certain cell lines. In this study, polyclonal anti-dsDNA antibody was isolated from the serum of a patient with active SLE, and was shown to substantially accelerate apoptosis in neutrophils from SLE patients as compared with neutrophils from healthy control or rheumatoid arthritis subjects.