Insulin Sensitivity and Liver Fat: Role of Iron Load
Insulin Sensitivity and Liver Fat: Role of Iron Load
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DOI：
10.1210/jc.2010-2682
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发表时间：
2011-06-01
影响因子：
5.8
通讯作者：
Thamer, Claus
中科院分区：
文献类型：
--
作者：
Haap, Michael;Machann, Juergen;Thamer, Claus
背景：肝脏脂肪(LF)增加与胰岛素抵抗有关。然而，在低频和胰岛素敏感性(IS)之间观察到相当大的个体差异，并且在同等水平的LF中，发现胰岛素抵抗和胰岛素敏感的个体。目的：我们的目的是研究肝铁负荷(HIL)是否可以解释IS和LF之间的一些差异。设计：使用定量T2*磁共振梯度回波成像技术测量HIL，并通过(1)H-磁共振波谱测量LF。低T2*值表示高HIL。我们研究了LF和HIL与人体测量数据和IS之间的关系。结果：调整年龄的T2*值与血清铁蛋白水平呈负相关(P<；0.0001)，与IS呈正相关(P=0.009)。T2*值与LF值相关(P=0.008)，与体重指数无关(P=0.60)。在多变量模型中，调整了性别、年龄和体重指数与T2*值相关(P=0.015)。经性别和年龄调整后，与LF(P=0.033)和T2*值(P=0.004)独立相关。在逐步回归分析中，Lf可解释IS变异的13.5%(P<0.01)，HIL可解释额外的4.1%(P=0.03)。结论：HIL可解释Lf与IS之间的部分变异。铁负荷诱导胰岛素抵抗的机制可能与脂肪肝引起的胰岛素抵抗的途径无关。(J Clin Endocrinol Metab 96：E958-E961,2011)
Context: Increased liver fat (LF) is associated with insulin resistance. However, a considerable individual variability between LF and insulin sensitivity (IS) is observed, and at equal levels of LF, insulin-resistant as well as insulin-sensitive individuals are found.Objective: Our objective was to study whether hepatic iron load (HIL) explains some of the variation between IS and LF.Design: HIL was measured using a quantitative T2* magnetic resonance gradient echo imaging technique, and LF was measured by (1)H-magnetic resonance spectroscopy. Low T2* values indicate high HIL. We studied the association of LF and HIL with anthropometric data and IS. A total of 113 healthy nondiabetic subjects [69 females, 44 males; age 47 +/- 1 yr; body mass index (BMI) = 28.9 +/- 0.5 kg/m(2)] at increased risk for type 2 diabetes were included in the study.Results: T2* values adjusted for age negatively associated with serum ferritin levels (P < 0.0001) and positively associated with IS (P = 0.009). In addition, T2* values associated with LF (P = 0.008) but not with BMI (P = 0.6). In a multivariate model, IS adjusted for gender, age, and BMI was associated with T2* values (P = 0.015). IS adjusted for gender and age was independently associated with LF (P = 0.033) and T2* values (P = 0.004). In a stepwise regression analysis, LF explained 13.5% (P < 0.01) of the variation in IS, and HIL explained an additional 4.1% (P = 0.03).Conclusions: HIL explains part of the variation between LF and IS. The mechanism by which iron load induces insulin resistance is possibly independent of the pathways involved in insulin resistance induced by fatty liver disease. (J Clin Endocrinol Metab 96: E958-E961, 2011)