Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis
Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis
复制标题
DOI：
10.1136/ard.2007.077297
复制
发表时间：
2008-07-01
影响因子：
27.4
通讯作者：
Pelletier, J-P
中科院分区：
文献类型：
--
作者：
Boileau, C.;Martel-Pelletier, J.;Pelletier, J-P
目的：骨关节炎（OA）的结构变化发生在几十年的人类。MRI可以提供有关关节结构及其随时间变化的精确可靠信息。在这项研究中，我们研究了定量MRI在评估膝关节OA的实验性前交叉韧带（ACL）的OA.Methods狗模型的结构变化的可靠性：OA手术诱导5只狗的右膝前交叉韧带横断。在基线、术后4、8和26周使用1.5 T磁体进行高分辨率三维MRI。在MRI图像上评估了软骨体积/厚度、软骨缺损、股骨髁骨赘形成和软骨下骨病变（高信号）。手术后26周处死动物，进行宏观evaluations.Results：随着时间的推移，膝关节软骨体积的损失，软骨缺损和软骨下骨高信号逐渐增加。trophobiar骨赘的大小也随着时间的推移而进展。最大的软骨损失在26周被发现在胫骨平台和内侧间室。有一个高度显着的相关性之间的总膝关节软骨体积损失或缺陷和软骨下骨高信号，也是一个很好的相关性之间的宏观和MRI findings.Conclusion：这项研究表明，MRI是一种有用的技术，提供了一个非侵入性和可靠的评估关节结构的变化，在发展过程中的OA在ACL狗模型。这种骨关节炎模型与MRI评估的结合为评估新的疾病缓解骨关节炎药物（DMOAD）提供了一种有前途的工具。
Objectives: Osteoarthritis (OA) structural changes take place over decades in humans. MRI can provide precise and reliable information on the joint structure and changes over time. In this study, we investigated the reliability of quantitative MRI in assessing knee OA structural changes in the experimental anterior cruciate ligament (ACL) dog model of OA.Methods: OA was surgically induced by transection of the ACL of the right knee in five dogs. High resolution three dimensional MRI using a 1.5 T magnet was performed at baseline, 4, 8 and 26 weeks post surgery. Cartilage volume/thickness, cartilage defects, trochlear osteophyte formation and subchondral bone lesion (hypersignal) were assessed on MRI images. Animals were killed 26 weeks post surgery and macroscopic evaluation was performed.Results: There was a progressive and significant increase over time in the loss of knee cartilage volume, the cartilage defect and subchondral bone hypersignal. The trochlear osteophyte size also progressed over time. The greatest cartilage loss at 26 weeks was found on the tibial plateaus and in the medial compartment. There was a highly significant correlation between total knee cartilage volume loss or defect and subchondral bone hypersignal, and also a good correlation between the macroscopic and the MRI findings.Conclusion: This study demonstrated that MRI is a useful technology to provide a non-invasive and reliable assessment of the joint structural changes during the development of OA in the ACL dog model. The combination of this OA model with MRI evaluation provides a promising tool for the evaluation of new disease-modifying osteoarthritis drugs (DMOADs).