Lessons learned and applied What the 20th century vaccine experience can teach us about vaccines in the 21st century
Lessons learned and applied What the 20th century vaccine experience can teach us about vaccines in the 21st century
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DOI：
10.4161/hv.19204
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发表时间：
2012-05-01
影响因子：
4.8
通讯作者：
Odoms, La' Nyia J.
中科院分区：
文献类型：
--
作者：
Hebert, Corey Joseph;Hall, Corey M.;Odoms, La' Nyia J.
在美国，大部分疫苗已纳入婴儿和幼儿的疫苗接种计划，这些年龄组特别容易感染传染病。尽管婴儿疫苗接种取得了成功，但疫苗接种覆盖率低的时期以及某些疫苗有限的免疫原性和保护期导致了零星爆发，使一些疾病在社区中传播。这些挑战表明，扩大疫苗接种覆盖范围，以更年轻的婴儿和青少年，和更多的免疫原性疫苗，可能需要在某些counts.This审查的重点是婴儿免疫接种的重要性，并探讨了目前的儿童早期疫苗接种计划的成功和挑战，以及如何将这些经验教训可能适用于其他侵袭性疾病，如脑膜炎球菌病。
Most vaccines available in the United States (US) have been incorporated into vaccination schedules for infants and young children, age groups particularly at risk of contracting infectious diseases. High universal vaccination coverage is responsible for substantially reducing or nearly eliminating many of the diseases that once killed thousands of children each year in the US.Despite the success of infant vaccinations, periods of low vaccination coverage and the limited immunogenicity and duration of protection of certain vaccines have resulted in sporadic outbreaks, allowing some diseases to spread in communities. These challenges suggest that expanded vaccination coverage to younger infants and adolescents, and more immunogenic vaccines, may be needed in some instances.This review focuses on the importance of infant immunization and explores the successes and challenges of current early childhood vaccination programs and how these lessons may be applied to other invasive diseases, such as meningococcal disease.