REPLICATION OF A STUDY OF FREQUENCY-ANALYSIS OF THE RESTING AWAKE EEG IN MILD PROBABLE ALZHEIMERS-DISEASE
REPLICATION OF A STUDY OF FREQUENCY-ANALYSIS OF THE RESTING AWAKE EEG IN MILD PROBABLE ALZHEIMERS-DISEASE
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DOI：
10.1016/0013-4694(90)90168-j
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发表时间：
1990-03-01
期刊：
影响因子：
--
通讯作者：
STORANDT, M
中科院分区：
文献类型：
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作者：
COBEN, LA;CHI, D;STORANDT, M
在静息脑电图中，在两个受试者样本的枕骨顶点推导中计算了 delta、theta、alpha 和 beta 频带的百分比功率以及平均频率。原始样本 (n = 79) 和新样本 (n = 43) 各包含一个轻度疑似阿尔茨海默病 (SDAT) 组和一个健康老年人对照组。两个样本中 SDAT 的组中位数 delta 和 theta 均高于健康受试者，而 alpha 和 beta 百分比以及平均频率则较低。两个样本的百分比 θ 和平均频率一致，显示 SDAT 和健康组之间存在统计显着差异。评估了每种 EEG 测量检测具有 SDAT 的个体受试者的能力。最有效的测量方法，即百分比 θ，仅具有适度的敏感性（约 20%），但这是在 100% 的特异性下实现的。对轻度阶段个体的准确检测要求阳性检测的预测价值较高，以避免将非 SDAT 受试者错误分类为 SDAT。反过来，当患病率较低时，这需要几乎 100% 的特异性。低灵敏度对脑电图的实用性造成了一些限制。因此，当痴呆症处于轻度阶段时，脑电图仅在某些限制条件下才可能成为阿尔茨海默病的有用检测器，这些限制条件包括高患病率、高特异性以及愿意接受高假阴性测试率。
In the resting EEG, the percentage power in the delta, theta, alpha, and beta bands and the mean frequency were computed in an occipital-vertex derivation for two samples of subjects. The original sample (n = 79) and the new sample (n = 43) each contained a mild probably Alzheimer''s disease (SDAT) group and a healthy elderly control group. Group medians in both samples were higher in the SDAT than in the healthy subjects for percentage delta and theta, and were lower for percentage alpha and beta and for mean frequency. Percentage theta and mean frequency were consistent across the two samples in showing statistically significant differences between SDAT and healthy groups. The ability of each EEG measure to detect individual subjects with SDAT was assessed. The most effective measure, percentage theta, had only modest sensitivity (about 20%), but this was attained at a specificity of 100%. The accurate detection of an individual at the mild stage requires that the predictive value of a positive test be high to avoid misclassification of non-SDAT subjects as SDAT. This, in turn, requires a specificity of virtually 100% when the prevalence is low. The low sensitivity puts several constraints on the usefulness of the EEG. For this reason, when the dementia is at the mild stage the EEG would be a useful detector of probably Alzheimer''s disease only under certain limiting conditions, including high prevalence, high specificity, and a willingness to accept a high rate of falsely negative tests.