Secretion of a new growth factor, smooth muscle cell derived growth factor, distinct from platelet derived growth factor by cultured rabbit aortic smooth muscle cells
Secretion of a new growth factor, smooth muscle cell derived growth factor, distinct from platelet derived growth factor by cultured rabbit aortic smooth muscle cells
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培养兔主动脉平滑肌细胞分泌一种新的生长因子——平滑肌细胞衍生生长因子，与血小板衍生生长因子不同
DOI：
10.1016/0014-5793(88)80668-9
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发表时间：
1988
期刊：
影响因子：
3.5
通讯作者：
S. Yoshida
中科院分区：
文献类型：
--
作者：
N. Morisaki;T. Kanzaki;T. Koshikawa;Y. Saito;S. Yoshida
在试图确定动脉平滑肌细胞（SMC）在内膜粥样硬化病变的增殖机制，SMC的自分泌生长因子最近受到了广泛的关注。本文报道了一种新的生长因子--平滑肌细胞衍生生长因子（smooth muscle cell derived growth factor，SDGF）。培养的兔中膜SMC在无血清培养基中孵育1周后，仅在至少4代后才分泌SDGF。SDGF在物理化学、免疫学和生物学上不同于血小板衍生生长因子（PDGF）。SDGF的性质似乎也不同于其他已知的刺激间充质细胞增殖的生长因子。
In attempts to determine the mechanism of proliferation of arterial smooth muscle cells (SMC) in intimal atheromatous lesions, autocrine secretion of growth factors by SMC has recently received much attention. Here we report a new growth factor named smooth muscle cell derived growth factor (SDGF). Cultured rabbit medial SMC secreted SDGF for 1 week during their incubation in serum-free media only after at least 4 passages. SDGF differed from platelet derived growth factor (PDGF) physicochemically, immunologically, and biologically. The properties of SDGF also seemed different from those of other known growth factors that stimulate the proliferation of mesenchymal cells.
DOI：
10.1073/pnas.83.19.7311
发表时间：
1986-10-01
影响因子：
11.1
作者：
WALKER, LN;BOWENPOPE, DF;REIDY, MA
通讯作者：
REIDY, MA
人血小板衍生生长因子。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Deuel,TF;Huang,JS;Proffitt,RT;Baenziger,JU;Chang,D;Kennedy,BB
通讯作者：
Kennedy,BB