Cross-sectional study of platinum salts sensitization among precious metals refinery workers.
Cross-sectional study of platinum salts sensitization among precious metals refinery workers.
复制标题
贵金属精炼厂工人对铂盐过敏的横断面研究。
DOI：
10.1002/ajim.4700180604
复制
发表时间：
1990
影响因子：
3.5
通讯作者：
Bernstein,IL
中科院分区：
文献类型：
--
作者：
Baker,DB;Gann,PH;Brooks,SM;Gallagher,J;Bernstein,IL
进行了一项横断面医学评估，以确定贵金属二级精炼厂工人中铂盐致敏的呼吸和皮肤病学影响。因呼吸道症状平均被解雇5年的107名现任员工中有15名和29名前员工中有8名（28%）对铂盐呈皮肤反应阳性。铂盐皮肤反应性与员工当前工作区域的铂盐平均空气浓度显著相关。铂盐皮肤试验阳性的工人比皮肤试验阴性的工人有更高的鼻炎、哮喘和皮炎的患病率。他们还增加了支气管反应冷空气的挑战和血清总IgE水平升高。铂盐致敏性与通过对常见空气过敏原的敏感性测量的特应性倾向无关，但与吸烟状态密切相关。研究结果表明，吸烟可能是铂盐过敏发生的危险因素。铂盐致敏的持续性和前工人中不良健康结果的高患病率证明了定期医疗监测的重要性，以便在致敏工人出现长期健康问题之前将其从暴露中移除。
A cross‐sectional medical evaluation was conducted to determine respiratory and dermatological effects of platinum salts sensitization among workers in a secondary refinery of precious metals. Fifteen of 107 current employees and eight (28%) of 29 former employees, who had been terminated from employment on average for 5 years because of respiratory symptoms, had positive skin reactivity to platinum salts. Platinum salts skin reactivity was significantly associated with average air concentrations of platinum salts in employees' present work area. Workers with positive platinum salts skin tests had significantly higher prevalences of reported rhinitis, asthma, and dermatitis than negative skin test workers. They also had increased bronchial response to cold air challenge and elevated levels of total serum IgE. Platinum salts sensitization was not associated with atopic tendency as measured by sensitivity to common aeroallergens, but was strongly associated with cigarette smoking status. The findings indicate that cigarette smoking may be a risk factor for the development of platinum salts allergy. The persistence of platinum salts sensitization and high prevalence of adverse health outcomes among former workers demonstrate the importance of regular medical monitoring so that sensitized workers can be removed from exposure before they develop long‐term health problems.