Use of neuromelanin-sensitive MRI to distinguish schizophrenic and depressive patients and healthy individuals based on signal alterations in the substantia nigra and locus ceruleus
Use of neuromelanin-sensitive MRI to distinguish schizophrenic and depressive patients and healthy individuals based on signal alterations in the substantia nigra and locus ceruleus
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DOI：
10.1016/j.biopsych.2008.03.021
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发表时间：
2008-09-01
影响因子：
10.6
通讯作者：
Sakai, Akio
中科院分区：
文献类型：
--
作者：
Shibata, Eri;Sasaki, Makoto;Sakai, Akio
背景：我们使用神经黑素敏感的磁共振成像(MRI)技术研究了精神分裂症和抑郁症患者黑质致密部(SNC)和蓝斑(LC)的变化，并检验了该技术是否可以区分这些疾病和健康受试者。方法：使用神经黑色素敏感的T1加权MRI技术，我们检查了20名精神分裂症患者、18名抑郁症患者和34名健康对照组。结果：精神分裂症患者黑质对比度(22.6+/-5.6)显著高于抑郁症(19.2+/-4.7)和健康对照组(19.6+/-3.8)，而抑郁症患者LC的CR(7.7+/-2.4)显著低于正常对照组(11.0+/-3.9)和精神分裂症患者(10.0+/-3.1)。此外，精神分裂症患者SNC和LC之间的CR差异(12.6+/-6.7)显著大于对照组(8.6+/-4.1)。结论：神经黑素敏感的MRI可以直观地显示精神分裂症和抑郁症患者SNC和LC的变化。
Background: We investigated alterations in the substantia nigra pars compacta (SNc) and locus ceruleus (LC) in schizophrenic and depressive patients by using a neuromelanin-sensitive magnetic resonance imaging (MRI) technique that enables direct visualization of these nuclei and examined whether this technique could distinguish between these disorders and healthy subjects.Methods: Using a neuromelanin-sensitive T1-weighted MRI technique, we examined 20 schizophrenia patients, 18 depressive patients, and 34 healthy control subjects. The signal intensities of the areas corresponding to the SNc and LC were measured, and the contrast ratios (CR) to the adjacent white matter were calculated.Results: The CR of the SNc was significantly higher in schizophrenic patients (22.6 +/- 5.6) than in depressive patients (19.2 +/- 4.7) and healthy control subjects (19.6 +/- 3.8), whereas the CR of the LC in depressive patients (7.7 +/- 2.4) was significantly lower than that in healthy control subjects (11.0 +/- 3.9) and schizophrenic patients (10.0 +/- 3.1). Further, the difference in the CR between the SNc and LC was significantly greater in schizophrenic patients (12.6 +/- 6.7) than in control subjects (8.6 +/- 4.1).Conclusions: Neuromelanin-sensitive MRI enables visualization of alterations in the SNc and LC that are observed in schizophrenia and depression.