Neurogenesis in humans
Neurogenesis in humans
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DOI：
10.1111/j.1460-9568.2011.07616.x
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发表时间：
2011-03-01
影响因子：
3.4
通讯作者：
Faull, Richard L. M.
中科院分区：
文献类型：
--
作者：
Curtis, Maurice A.;Kam, Monica;Faull, Richard L. M.
自1944年以来，越来越多的证据表明，成人大脑中含有能够产生神经母细胞的祖细胞。然而，直到1998年，这一事实才在成年人的大脑中得到证实。随着人类神经发生目的的激烈争论，许多研究小组将注意力集中在大脑中神经退行性疾病的影响上，以确定内源性再生反应的强度。尽管大多数人类研究都集中在海马体上，但有大量证据表明，在脑室下区和脑室-嗅神经系统中有更大的可塑性。在这篇综述中，我们提出了在不同疾病和不同药物治疗下成人大脑可塑性和神经发生增加或减少的证据。虽然对人类神经发生的研究很少，但足以得出一些关于人脑可塑性潜力的结论。
Since 1944 increasing evidence has been emerging that the adult human brain harbours progenitor cells with the potential to produce neuroblasts. However, it was not until 1998 that this fact was confirmed in the adult human brain. With the purpose of human neurogenesis being hotly debated, many research groups have focussed on the effect of neurodegenerative diseases in the brain to determine the strength of the endogenous regenerative response. Although most of the human studies have focussed on the hippocampus, there is a groundswell of evidence that there is greater plasticity in the subventricular zone and in the ventriculo-olfactory neurogenic system. In this review, we present the evidence for increased or decreased plasticity and neurogenesis in different diseases and with different drug treatments in the adult human brain. Whilst there is a paucity of studies on human neurogenesis, there are sufficient to draw some conclusions about the potential of plasticity in the human brain.