Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones.
Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones.
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DOI：
10.1038/srep43380
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发表时间：
2017-02-27
影响因子：
4.6
通讯作者：
Zeng F
中科院分区：
文献类型：
--
作者：
Li Y;Cheng Y;Xie Z;Zeng F
本文对广东、广西、海南三省202份人群血清中8种全氟烷基物质（PFASs）和5种甲状腺激素（TSH、FT_4、FT_3、TGAb和TMAb）进行了测定。PFASs浓度范围为0.85 - 24.3 ng/mL，平均值为4.66 ng/mL。不同地点的人血清样品中PFASs的组成几乎没有差异。随着年龄的增长，∑ 8 PFASs、PFOS和PFHxS浓度显著增加（p < 0.01）。发现了与性别有关的差异;男性的全氟辛烷磺酸、全氟辛烷磺酸、全氟辛烷磺酸和全氟辛酸水平较高（p < 0.05），男性的∑ 8全氟辛烷磺酸平均浓度（6.02纳克/毫升）是女性（4.15纳克/毫升）的1.5倍。PFOS和∑ 8 PFASs与FT 3、FT 4呈显著负相关，与TSH呈显著正相关，PFPeA和PFHxA与TGAb和TMAb呈显著正相关。甲减组和甲亢组的FT 3、TSH与PFOS、PFOA和PFHxS呈相反的相关关系，提示PFOS、PFOA和PFHxS增强了甲状腺的负反馈机制。
In this study, eight perfluorinated alkyl substances (PFASs) and five thyroid hormones (TSH, FT4, FT3, TGAb, and TMAb) were determined in 202 human serum samples of the general population of Guangdong, Guangxi and Hainan provinces in southern China. Σ8PFASs concentrations ranged from 0.85 to 24.3 ng/mL with a mean value of 4.66 ng/mL. The PFASs composition profiles of human serum samples nearly make no difference at different locations. A significant increase was observed for ∑8PFASs, PFOS, and PFHxS concentrations with age (p < 0.01). Gender-related differences were found; PFOS, PFHxS, PFBS, and PFOA levels were higher in males (p < 0.05), and the mean concentration of ∑8PFASs was 1.5 times greater in males (6.02 ng/mL) than in females (4.15 ng/mL). PFOS and ∑8PFASs were significantly negatively correlated with FT3 and FT4 and positively correlated with TSH while PFPeA and PFHxA were significantly positively correlated with TGAb and TMAb in all the samples. The opposite associations between FT3, TSH and PFOS, PFOA and PFHxS levels in hypothyroidism and hyperthyroidism group indicate that the PFOS, PFOA and PFHxS enhance the negative feedback mechanisms of the thyroid gland.