Memory-related hippocampal dysfunction in poly-drug ecstasy (3,4-Methylenedioxymethamphetamine) users
Memory-related hippocampal dysfunction in poly-drug ecstasy (3,4-Methylenedioxymethamphetamine) users
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DOI：
10.1007/s00213-004-2002-8
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发表时间：
2005-08-01
影响因子：
3.4
通讯作者：
Gouzoulis-Mayfrank, E
中科院分区：
文献类型：
--
作者：
Daumann, J;Fischermann, T;Gouzoulis-Mayfrank, E
Rationale: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is neurotoxic in animal studies and its use has been associated with cognitive impairments in humans. Objective: To study hippocampal activation during the retrieval from episodic memory in polyvalent users of ecstasy. Methods: Twelve polyvalent ecstasy users and twelve matched controls were examined by means of functional magnetic resonance imaging (fMRI) while they retrieved face-profession associations from episodic memory. Results: Ecstasy users had a normal structural MRI scan without focal brain lesions or anatomical abnormalities. They exhibited equal retrieval accuracy during memory retrieval to that of the matched controls. Yet, their retrieval-related activity was lower and more spatially restricted in the left anterior hippocampus than that of the controls. Conclusions: These results provide evidence for abnormal hippocampal. functioning in MDMA users even at the presence of normal memory performance. This finding may be linked to MDMA-induced neurotoxicity and suggests that diminished hippocampal activation during memory retrieval might be a more sensitive or earlier index of MDMA-relatcd neurotoxicity than neuropsychological performance.
