Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia
Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia
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DOI：
10.1007/s00198-004-1802-3
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发表时间：
2005-09-01
影响因子：
4
通讯作者：
Kawase, M
中科院分区：
文献类型：
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作者：
Ito, M;Nishida, A;Kawase, M
我们确定了利塞膦酸钠对卵巢切除大鼠胫骨骨小梁显微结构的影响，使用显微计算机断层扫描，以研究如何在微观结构的变化有助于生物力学性能。50只18周龄大鼠接受假手术（n=10）或卵巢切除术（OVX）（n=40）。将去卵巢大鼠进一步分为4组（每组n=10），并以0、0.1、0.5或2.5mg/kg的剂量用利塞膦酸钠治疗9个月。OVX导致三维骨小梁显微结构的恶化，特别是结构模型指数（SMI）和连接密度，而0.5和2.5 mg/kg的利塞膦酸钠治疗OVX大鼠改善这些有害的显微结构变化。生物力学性能，通过有限元分析（FEA）评估，与骨小梁体积分数（BV/TV）显着相关性，并进一步增加了微结构参数时，特别是SMI和连接密度，与利塞膦酸钠治疗。因此，这表明，除了增加骨量，利塞膦酸盐通过保持板状结构以及骨小梁的连接性来改善生物力学性能。
We determined the effect of risedronate on the trabecular microstructure of ovariectomized rat tibiae, using micro-computed tomography, in order to investigate how changes in microstructure contribute to biomechanical properties. Fifty 18-week-old rats underwent sham operation (n=10) or ovariectomy (OVX) (n=40). The OVX rats were further divided into four groups (n=10 for each group) and treated with risedronate at doses of 0, 0.1, 0.5 or 2.5 mg/kg for 9 months. OVX caused deterioration of three-dimensional trabecular microstructure, notably structure model index (SMI) and connectivity density, while treatment of OVX rats with risedronate at 0.5 and 2.5 mg/kg improved those deleterious microstructural changes. Biomechanical property, as assessed by finite element analysis (FEA), correlated significantly with trabecular bone volume fraction (BV/TV), and the correlation further increased substantially when microstructural parameters were added, especially SMI and connectivity density, with risedronate therapy. Thus, it is suggested that, in addition to increasing bone mass, risedronate improves biomechanical property by maintaining a plate-like structure as well as connectivity of trabeculae.