Parvovirus B19 infection in pregnancy - awareness and opportunities
Parvovirus B19 infection in pregnancy - awareness and opportunities
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DOI：
10.1016/j.coviro.2017.10.003
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发表时间：
2017-12-01
影响因子：
5.9
通讯作者：
Gallinella, Giorgio
中科院分区：
文献类型：
--
作者：
Bonvicini, Francesca;Bua, Gloria;Gallinella, Giorgio
细小病毒B19（B19 V）是一种与多种临床病症相关的人类致病性病毒。在怀孕期间，B19 V对胎儿构成潜在危害，因为它穿过胎盘屏障并感染骨髓和肝脏中的红系祖细胞，它阻断胎儿红细胞生成，导致严重贫血，水肿和/或胎儿死亡。该病毒不被视为致畸原，但对宫内感染的机制和后果以及新生儿发育中可能的后遗症有了更多的科学认识。建立可靠的诊断程序和胎儿管理策略，包括宫内输血。尽管是一种公认的可能导致胎儿丢失的促胎剂，但B19 V检测并不常规包括在孕前或产前筛查中，这可能会延迟B19 V并发症妊娠的管理。B19 V研究的不断进步将提供更好的诊断方法和算法，以及开发有效的预防性干预措施和新的治疗方案。
Parvovirus B19 (B19V) is a human pathogenic virus associated with a wide range of clinical conditions. In pregnancy, B19V poses a potential hazard to the fetus as crossing the placental barrier and infecting erythroid progenitor cells in bone marrow and liver, it blocks fetal erythropoiesis leading to profound anemia, hydrops and/or fetal death. The virus is not regarded as a teratogen, however more scientific awareness is emerging on mechanisms and consequences of intrauterine infection and possible sequelae in the neonatal development. Reliable diagnostic procedures and fetal management strategies, including intrauterine transfusion, are established. In spite of being a recognized fetotropic agent possibly leading to fetal loss, testing for B19V is not routinely included in preconception or antenatal screenings, possibly delaying the management of B19V-complicated pregnancies. Continuous advances in B19V research will provide for better diagnostic methods and algorithms, as well as for the development of effective prophylactic interventions and novel therapeutic options.