Low Rates of Acute Recanalization With Intravenous Recombinant Tissue Plasminogen Activator in Ischemic Stroke Real-World Experience and a Call for Action
Low Rates of Acute Recanalization With Intravenous Recombinant Tissue Plasminogen Activator in Ischemic Stroke Real-World Experience and a Call for Action
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DOI：
10.1161/strokeaha.110.592535
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发表时间：
2010-10-01
期刊：
影响因子：
8.3
通讯作者：
Demchuk, Andrew M.
中科院分区：
文献类型：
--
作者：
Bhatia, Rohit;Hill, Michael D.;Demchuk, Andrew M.
背景和目的：通常使用经颅多普勒（TCD）对静脉注射重组组织纤溶酶原激活剂（rt-PA）治疗近端血管闭塞后的急性再通率进行了保守估计。我们的目的是研究急性再通率的IV rt-PA在CT血管造影证实的近端（颈内动脉[伊卡]，M1大脑中动脉[MCA]，M2-MCA，和基底动脉）闭塞和他们的影响outcome.Materials和Methods的CT血管造影数据库的卡尔加里中风计划进行了审查，为2002年至2009年期间。所有接受IV rt-PA治疗并通过TCD或血管造影片（用于急性血管内治疗）评估再通的近端血管闭塞患者均纳入分析。记录TCD/首次血管造影观察到的急性再通率和血管内治疗后再通率。改良兰金量表评分
Background and Purpose-Acute rates of recanalization after intravenous (IV) recombinant tissue plasminogen activator (rt-PA) in proximal vessel occlusion have been estimated sparingly, typically using transcranial Doppler (TCD). We aimed to study acute recanalization rates of IV rt-PA in CT angiogram-proven proximal (internal carotid artery [ICA], M1 middle cerebral artery [MCA], M2-MCA, and basilar artery) occlusions and their effects on outcome.Materials and Methods-The CT angiogram database of the Calgary stroke program was reviewed for the period 2002 to 2009. All patients with proximal vessel occlusions receiving IV rt-PA who were assessed for recanalization by TCD or angiogram (for acute endovascular treatment) were included for analysis. Rates of acute recanalization as observed on TCD/first run of angiogram and postendovascular therapy recanalization rates were noted. Modified Rankin Scale score