Split Liver Transplantation
Split Liver Transplantation
复制标题
DOI：
10.1016/j.transproceed.2010.11.031
复制
发表时间：
2011-06-01
影响因子：
0.9
通讯作者：
Tzakis, A.
中科院分区：
文献类型：
--
作者：
Nesher, E.;Island, E.;Tzakis, A.
我们分析了1996年9月至2008年12月在我中心接受劈离式肝移植的55例患者的结果，其中30例成人（54.5%）和25例儿童（45.5%）。中位随访时间为12年。患者总生存率为71%，成人为70%，儿童为72%。平均患者生存期为61.58个月，平均移植物生存期为44.35个月。1年和5年后的儿童存活率和儿童移植物存活率分别为84%和72%以及72%和52.4%。1年和5年后的成人存活率和成人移植物存活率分别为75%和66.2%以及60.7%和51.5%。12例患者需要再次移植，6例为原发性无功能，3例为慢性排斥反应，3例为血管并发症。受者血型为O型34例，A型14例，B型7例，AB型0例。在成人和儿童人群中使用分割肝脏使我们能够扩大尸体供体库，并有可能显着降低等待名单死亡率，特别是对于某些血型。
We analyzed the results of 55 patients who underwent split liver transplantation at our center between September 1996 and December 2008, 30 adults (54.5%) and 25 children (45.5%). Median follow-up was 12 years. Overall patient survival was 71%, adult 70% and pediatric 72%. Mean patient survival was 61.58 months, and mean graft survival was 44.35 months. Pediatric survival and pediatric graft survival after 1 and 5 years were 84% and 72% and 72% and 52.4%, respectively. Adult survival and adult graft survival after 1 and 5 years were 75% and 66.2% and 60.7% and 51.5%, respectively. Twelve patients required retransplantation, 6 for primary nonfunction, 3 for chronic rejection, and 3 for vascular complications. Blood groups of the recipient patients were: 34 O, 14 A, 7 B, and 0 AB. The use of split liver for adult and pediatric populations allows us to expand the cadaveric donor pool and has the potential to significantly reduce waiting list mortality, especially for certain blood groups.