Novel t(8;17)(q23;q24.2) and t(9;22)(p24.1;q12.2) in acute megakaryoblastic leukemia AML-M7 subtype in an adult patient
Novel t(8;17)(q23;q24.2) and t(9;22)(p24.1;q12.2) in acute megakaryoblastic leukemia AML-M7 subtype in an adult patient
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DOI：
10.1016/j.cancergencyto.2009.04.018
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发表时间：
2009-09-01
影响因子：
--
通讯作者：
Mandava, Swarna
中科院分区：
文献类型：
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作者：
Ahmad, Firoz;Dalvi, Rupa;Mandava, Swarna
诊断核型与临床结局的密切联系使细胞遗传学成为急性髓系白血病(AML)最有价值的诊断和预后工具之一。M7亚型是一种罕见的巨核细胞系疾病，主要与复杂的异常核型有关。我们描述了一例39岁的急性巨核细胞白血病(AML-M7)患者的临床、形态、免疫表型和细胞遗传学表现。细胞遗传学分析发现两个易位，t(8；17)(q23；q24.2)和t(9；22)(p24.1；q12.2)，据我们所知，这种组合是急性巨核细胞白血病的新发现。患者对诱导治疗有反应，治疗9天后完全缓解。(C)2009 Elsevier Inc.保留所有权利。
The strong association of diagnostic karyotype with clinical outcome has made cytogenetics one of the most valuable diagnostic and prognostic tools for acute myeloid leukemia (AML). The subtype M7 is a rare disease of the megakaryoblastic lineage and is mostly associated with complex abnormal karyotype. We describe the clinical, morphologic, immunophenotypic, and cytogenetic findings in the case of a 39-year-old man with acute megakaryoblastic leukemia (AML-M7). Cytogenetic analysis revealed two translocations, t(8;17)(q23;q24.2) and t(9;22)(p24.1;q12.2), at presentation; to our knowledge, this combination is a novel finding for acute megakaryoblastic leukemia. The patient responded to induction therapy, achieving complete remission after 9 days of therapy. (C) 2009 Elsevier Inc. All rights reserved.