Does inhaled pollen enter the sinus cavities?
Does inhaled pollen enter the sinus cavities?
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DOI：
10.1016/s1081-1206(10)62807-4
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发表时间：
1998-08-01
影响因子：
5.9
通讯作者：
Slavin, RG
中科院分区：
文献类型：
--
作者：
Adkins, TN;Goodgold, HM;Slavin, RG
背景资料：虽然有证据表明，过敏性鼻炎患者的鼻窦炎的发病率增加，目前还不清楚是否过敏过程中发生的窦tissuespers.Objective：本研究的目的是确定是否吸入花粉到达窦mucosal.Methods：Tc 99 m标记豚草花粉吸入5个非过敏性成人。使用断层旋转伽马照相机对鼻窦进行成像研究。为了确定该技术的灵敏度，鼻子和上颌窦的尸体头部涂有不同量的Tc 99 m，然后同样scanned.Results：扫描的尸体头部显示清晰的分辨率之间的鼻腔和上颌窦。经测定，20 μ Ci是窦中可分辨的最小Tc 99 m量。扫描显示强烈的活动，在鼻腔，但没有在鼻窦，尽管交付的超生理剂量的Tc 99 m豚草pollent.Conclusion：吸入豚草花粉不会出现进入鼻窦。吸入性抗原-IgE抗体反应不太可能发生在鼻窦粘膜中。
Background: While there is evidence of an increased incidence of sinusitis in patients with allergic rhinitis, it is unclear whether an allergic process occurs in the sinus tissues per se.Objective: The purpose of this study was to determine whether inhaled pollen reaches the sinus mucosa.Methods: Tc99m labeled ragweed pollen was inhaled by five non-atopic adults. Imaging studies of the sinuses were performed with a tomographic rotating gamma camera. To determine the sensitivity of the technique, the nose and the maxillary sinuses of cadaver heads were painted with varying amounts of Tc99m and then similarly scanned.Results: Scans of the cadaver heads showed clear resolution between the nasal cavity and the maxillary sinus. It was determined that 20 mu ci was the smallest amount of Tc99m that could be resolved to be in the sinuses. Scans of subjects showed intense activity in the nasal cavity but none in the paranasal sinuses despite the delivery of a supraphysiologic dose of Tc99m ragweed pollen.Conclusion: Inhaled ragweed pollen does not appear to enter the paranasal sinuses. It is unlikely that an inhaled antigen-IgE antibody reaction occurs in the sinus mucosa.