RADIONUCLIDE IMAGING OF OVARIAN-TUMORS WITH I-123-LABELED MONOCLONAL-ANTIBODY (NDOG2) DIRECTED AGAINST PLACENTAL ALKALINE-PHOSPHATASE
RADIONUCLIDE IMAGING OF OVARIAN-TUMORS WITH I-123-LABELED MONOCLONAL-ANTIBODY (NDOG2) DIRECTED AGAINST PLACENTAL ALKALINE-PHOSPHATASE
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DOI：
10.1111/j.1471-0528.1985.tb01095.x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
SUNDERLAND, CA
中科院分区：
文献类型：
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作者：
DAVIES, JO;DAVIES, ER;SUNDERLAND, CA
应用一种靶向胎盘碱性磷酸酶（PLAP）的放射标记单克隆抗体（NDOG2）用于卵巢癌的放射免疫检测。在15例患者中，有11例成功地观察到肿瘤沉积，所显示的异常分为局灶性或弥漫性。11例患者中，8例仅表现为局灶性异常，3例表现为弥漫性异常，其中2例同时表现为局灶性异常。假阳性结果的出现不仅可能是由于肠道黏膜对123I的吸收和甲状腺阻塞不充分，也可能是由于膀胱未完全排空。假阴性结果的发生是由于肝脏中高背景活性掩盖了已知的、离散的肿瘤沉积。
A radiolabeled monoclonal antibody (NDOG2) directed against placental alkaline phosphatase (PLAP) was used in the radioimmunodetection of ovarian carcinoma. Tumor deposits were successfully visualized in 11 of 15 patients and the abnormalities demonstrated were classified as focal or diffuse. Of the 11 patients, 8 showed focal abnormalities alone and 3 had a diffuse abnormality, of which 2 also showed a focal abnormality. False-positive results may occur not only due to uptake of 123I by gut mucosa and an inadequately blocked thyroid gland but also from activity in an incompletely emptied bladder. A false-negative result occurred due to high background activity in the liver masking a known, discrete tumor deposit.