VACCINATION AGAINST EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS WITH T-CELL RECEPTOR PEPTIDES
VACCINATION AGAINST EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS WITH T-CELL RECEPTOR PEPTIDES
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DOI：
10.1126/science.2814489
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发表时间：
1989-11-03
期刊：
影响因子：
56.9
通讯作者：
BROSTOFF, SW
中科院分区：
文献类型：
--
作者：
HOWELL, MD;WINTERS, ST;BROSTOFF, SW
实验性变态反应性脑脊髓炎（EAE）是一种由髓鞘碱性蛋白（MBP）介导的CD4+ T细胞介导的中枢神经系统自身免疫性疾病。通过用对应于β的独特型决定子的合成肽接种，使大鼠对EAE的诱导具有抗性。链区和J α.在致脑炎T细胞中保守的T细胞受体（TCR）区域。这些发现证明了TCR肽疫苗接种用于调节自身反应性T细胞的活性的效用，并代表了T细胞介导的发病机制的一般治疗方法。
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system mediated by CD4+ T cells reactive with myelin basic protein (MBP). Rats were rendered resistant to the induction of EAE by vaccination wiht synthetic peptides corresponding ot idiotypic determinants of the .beta. chain region and J.alpha. regions of the T cell receptor (TCR) that are conserved among encephalitogenic T cells. These findings demonstrate the utility of TCR peptide vaccination for modulating the activity of autoreactive T cells and representing a general therapeutic approach for T cell-mediated pathogenesis.