Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats
Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats
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DOI：
10.1016/j.jphs.2021.06.004
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发表时间：
2021-06-23
影响因子：
3.5
通讯作者：
Iwasaki, Katsunori
中科院分区：
文献类型：
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作者：
Egashira, Nobuaki;Goto, Yu;Iwasaki, Katsunori
奥沙利铂是用于治疗结直肠癌等实体瘤的关键药物；然而，它会导致周围神经病变。在这项研究中，我们研究了异丁司特（一种磷酸二酯酶抑制剂）对奥沙利铂诱导的大鼠机械性异常性疼痛和组织学变化的影响。异丁司特（7.5 mg/kg，腹腔注射，每周 5 次）可减少奥沙利铂（4 mg/kg，腹腔注射，每周两次）引起的机械性异常性疼痛和组织学变化。相反，异丁司特（0.01-10μM）对奥沙利铂诱导的小鼠结肠腺癌细胞26细胞的肿瘤细胞毒性没有影响。这些发现表明，异丁司特可用于预防临床环境中奥沙利铂引起的周围神经病变。 (C) 2021 作者。由 Elsevier B.V. 代表日本药理学会制作和主办。
Oxaliplatin is a key drug used in the management of solid tumors, such as colorectal cancer; however, it causes peripheral neuropathy. In this study, we investigated the effect of ibudilast, a phosphodiesterase inhibitor, on oxaliplatin-induced mechanical allodynia and histological changes in rats. Ibudilast (7.5 mg/kg, i.p., 5 times per week) reduced mechanical allodynia and histological changes induced by oxaliplatin (4 mg/kg, i.p., twice a week). In contrast, ibudilast (0.01-10 mu M) had no effect on oxaliplatin-induced tumor cytotoxicity in murine colon adenocarcinoma 26 cells. These findings suggest that ibudilast could be useful for preventing oxaliplatin-induced peripheral neuropathy in clinical settings. (C) 2021 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.