HLA genes in Mayos population from northeast Mexico
HLA genes in Mayos population from northeast Mexico
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DOI：
10.2174/138920207783591735
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发表时间：
2007-11-01
期刊：
影响因子：
2.6
通讯作者：
Vargas-Alarcon, G.
中科院分区：
文献类型：
--
作者：
Arnaiz-Villena, A.;Moscoso, J.;Vargas-Alarcon, G.
在生活在墨西哥太平洋锡那罗亚州的60名无血缘关系的梅奥斯族人中，研究了人类白细胞抗原I类和II类等位基因。梅奥人的人类白细胞抗原图谱与其他美洲印第安人和世界各地人群的图谱进行了比较。共有14,896条染色体用于比较。通过群体间遗传距离、邻接树状图和对应分析来确定群体间的遗传关系。新发现的Mayo单倍型有：人类白细胞抗原-A*02-B*35-DRB1*1406-DQB1*0301；人类白细胞抗原-A*02-B*48-DRB1*0404-DQB1*0302；然而，典型的中美HLADRB1*0407代表了所有DRB1等位基因的40%。虽然在美洲印第安人中发现了共同的HLA特征，但仍有新的群体特有的单倍型被发现，这表明共同的创始人效应(即高DRB1*0407)被注意到。此外，几乎可以肯定的是，随着时间的推移，新的HLA单倍型正在出现，可能是由于特定的病原体(？)为了多样性而选择。梅奥语言与塔拉乌马拉语(另一个地理上相近的群体)很接近；尽管根据我们的结果，这两个群体在基因上并不接近，再次表明基因和语言的不同进化，这是不相关的。最后，锡那罗亚州是墨西哥发现更多欧洲基因的州之一。然而，在Mayos中没有发现欧洲的HLA基因的情况下，本文提出的结果应该对建立移植计划以及在人类白细胞抗原和疾病研究中有一定的影响。
HLA class I and class II alleles have been studied in 60 unrelated people belonging to Mayos ethnic group, which lives in the Mexican Pacific Sinaloa State. Mayos HLA profile was compared to other Amerindians and worldwide populations' profile. A total of 14,896 chromosomes were used for comparisons. Genetic distances between populations, Neigbour-Joining dendrograms and correspondence analyses were performed to determine the genetic relationship among population. The new specific Mayo HLA haplotypes found are: HLA-A*02-B*35-DRB1*1406-DQB1*0301; HLA-A*02-B*48-DRB1*0404-DQB1*0302; HLA-A*24-B*51-DRB1*0407-DQB1*0302 and HLA-A*02-B*08-DRB1*0407DQB1*0302. However, the typical Meso American HLADRB1*0407 represents a 40% of all DRB1 alleles. While common HLA characteristics are found in Amerindian distant ethnic groups, still new group specific HLA haplotypes are being found, suggesting that a common founder effect (i.e. high DRB1*0407) is noticed. Moreover, new HLA haplotypes are almost certainly appearing along time probably due to specific pathogen (?) selection for diversity. Mayo language is close to the Tarahumara one (another geographically close group); notwithstanding both groups are not genetically close according to our results, showing again the different evolution of genes and languages, which do not correlate. Finally, Sinaloa is one of the Mexican States in which more European genes are found. However, the results presented in this paper, where no European HLA genes are seen in Mayos, should have a bearing in establishing transplant programs and in HLA and disease studies.