Phase diagram of a 4-component lipid mixture: DSPC/DOPC/POPC/chol.
Phase diagram of a 4-component lipid mixture: DSPC/DOPC/POPC/chol.
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DOI:
10.1016/j.bbamem.2013.05.020
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发表时间:
2013-09
期刊:
影响因子:
--
通讯作者:
Feigenson GW
中科院分区:
文献类型:
--
作者:
Konyakhina TM;Wu J;Mastroianni JD;Heberle FA;Feigenson GW
We report the first 4-component phase diagram for the lipid bilayer mixture, DSPC/DOPC/POPC/chol (distearoylphosphatidylcholine/dioleoylphosphatidylcholine/1-palmitoyl, 2-oleoylphosphatidylcholine/cholesterol). This phase diagram, which has macroscopic Ld + Lo phase domains, clearly shows that all phase boundaries determined for the 3-component mixture containing DOPC transition smoothly into the boundaries for the 3-component mixture containing POPC, which has nanoscopic phase domains of Ld + Lo. Our studies start from two published ternary phase diagrams, and show how these can be combined into a quaternary phase diagram by study of a few hundred samples of intermediate compositions.
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