Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Meniere's Disease Patients: More than a Chance Association?
Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Meniere's Disease Patients: More than a Chance Association?
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DOI：
10.1159/000218357
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发表时间：
2010-01-01
影响因子：
1.6
通讯作者：
Fattori, Bruno
中科院分区：
文献类型：
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作者：
Nacci, Andrea;Dallan, Iacopo;Fattori, Bruno
目的/假设：这项前瞻性研究的目的是评估梅尼埃病（MD）和自身抗体之间的可能联系。研究方法：55例明确的MD患者（51例单侧和4例双侧）与55例单侧前庭轻瘫无耳蜗受累患者和55例健康受试者相匹配。采集所有研究受试者的血样，用于测定血清TSH、游离三碘甲状腺原氨酸、游离甲状腺素、抗TSH受体抗体、抗甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体和非器官特异性抗原抗体，即抗核抗体、可提取核抗原抗体和抗中性粒细胞胞质抗体。结果如下：MD组33例受试者（60%）有1种或多种血清自身抗体水平升高，包括器官和非器官特异性; 16例单侧前庭轻瘫患者（29.1%）有1种或多种血清自身抗体水平升高，而13例健康受试者（23.6%）有1种或多种血清自身抗体水平升高。结论：根据我们的数据，我们推测，有一个以上的机会MD和“自身免疫性”之间的关联，从而提出了一个假设的免疫系统在MD发病机制的作用。换句话说，可以假设MD患者中“免疫失调”的发病作用。版权所有（C）2009 S. Karger AG，巴塞尔
Objective/Hypothesis: The aim of this prospective study is to evaluate the possible association between Meniere's disease ( MD) and autoantibodies. Methods: Fifty-five patients with definite MD ( 51 unilateral and 4 bilateral) were matched with 55 patients with unilateral vestibular paresis without cochlear involvement and 55 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, anti-TSH receptor antibody, antithyroperoxidase antibody, antithyroglobulin antibody and of antibodies to non-organ-specific antigens, namely antinuclear antibodies, antibodies to extractable nuclear antigens and antineutrophilic cytoplasmic antibodies. Results: Thirty-three subjects (60%) of the MD group had 1 or more elevated serum autoantibody levels, both organ and non-organ specific; 16 patients (29.1%) with unilateral vestibular paresis had 1 or more elevated serum autoantibody levels, while 13 healthy subjects (23.6%) had 1 or more elevated serum autoantibody levels. Conclusions: Based on our data we speculate that there is a more than a chance association between MD and 'autoimmunity', thus suggesting a hypothetical role of the immune system in MD pathogenesis. In other words, a pathogenetic role of an 'immune dysregulation' in MD patients can be hypothesized. Copyright (C) 2009 S. Karger AG, Basel