SINGLE AUDITORY NEURON RESPONSE DURING ACUTE ACOUSTIC TRAUMA
SINGLE AUDITORY NEURON RESPONSE DURING ACUTE ACOUSTIC TRAUMA
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DOI：
10.1016/0378-5955(80)90004-0
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发表时间：
1980-01-01
期刊：
影响因子：
2.8
通讯作者：
JOHNSTONE, BM
中科院分区：
文献类型：
--
作者：
CODY, AR;JOHNSTONE, BM
通过记录豚鼠耳蜗螺旋神经节中的单个听觉神经元，可以监测同一神经元在急性暴露于长达180分钟的连续纯音（100 dB SPL[声压级]）时声刺激的阈值变化。调谐曲线的初始变化是特征频率（CF）及以上的灵敏度损失。这种不对称损耗导致CF向较低频率偏移。进一步曝光（长达20分钟）会导致调谐曲线的尖锐调谐部分完全丧失，与原始CF相比，最敏感的区域移动到较低的频率，最高可达0.75个倍频。短曝光（长达20分钟）可能会发生调谐曲线低频部分的敏化，但随着进一步曝光（无论是连续曝光还是中断曝光）消失。长期暴露（60-80分钟）会产生调谐曲线低频部分的损失，直到达到一个点，此时单元不再对110 dB SPL的刺激做出反应。
By recording from single auditory neurons in the spiral ganglion of the guinea pig cochlea it was possible to monitor threshold changes to acoustic stimuli in the same neuron during acute exposures to continuous pure tones (100 dB SPL [sound pressure level]) delivered for periods of up to 180 min. Initial changes in the tuning curve were sensitivity losses at and above the characteristic frequency (CF). This asymmetric loss resulted in a shift in the CF to lower frequencies. Further exposure (up to 20 min) produced a complete loss of the sharply tuned portion of the tuning curve and the most sensitive area moved to lower frequencies by up to 0.75 of an octave when compared to the original CF. Sensitization of the low frequency section of the tuning curve could take place for short exposures (up to 20 min) but disappeared with further exposure, whether continuous or interrupted. Long term exposures (60-80 min) produced losses in the low frequency portion of the tuning curve until a point was reached when the unit no longer responded to stimuli at 110 dB SPL.