Botrytis species:: An intriguing source of metabolites with a wide range of biological activities.: Structure, chemistry and bioactivity of metabolites isolated from Botrytis species
Botrytis species:: An intriguing source of metabolites with a wide range of biological activities.: Structure, chemistry and bioactivity of metabolites isolated from Botrytis species
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DOI：
10.2174/1385272003375815
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发表时间：
2000-12-01
影响因子：
2.6
通讯作者：
Durán-Patrón, R
中科院分区：
文献类型：
--
作者：
Collado, IG;Aleu, J;Durán-Patrón, R
灰霉病菌属于地理分布最广的植物病原菌和腐生菌类群，对许多经济作物造成严重损失。这些植物病原真菌是灰霉病的病原体。它们生物合成特有的代谢物，在体外会产生灰霉病症状。最近发现，当灰霉病菌侵染植物时，氧化力参与其中，以及毒素与致病性的相关性，这增加了人们对这些化合物的兴趣，以确定与植物氧自由基代谢和诱导氧化胁迫的潜在联系。本文综述了从葡萄孢属植物中分离得到的代谢物、波谱数据、按结构家族归类、合成和化学转化，特别是那些在葡萄孢烷骨架上进行的代谢产物。葡萄孢子的基本骨架是一个双环的非异戊二烯类倍半萜系统，这为许多关于该骨架的生物合成途径的研究提供了刺激。本文报道了该骨架的生物合成研究和不对称合成方法。另一方面，对这些代谢物的生物活性进行了详细的研究，并研究了这些代谢物与葡萄糖烷骨架的构效关系。
The Botrytis species belong to the most geographically widespread group of plant pathogens and saprophytes, and cause serious losses to very many commercial crops. These phytopathogenus fungi are the agents of the disease known as grey mould. They biosynthesise characteristic metabolites that, in vitro, produce the grey mould symptoms. The recent discovery that oxidative forces are involved when B. cinerea infects plant and the relevance of toxins for pathogenicity, have increased the interest for these compounds, in order to determinate the potential links to the plant oxyradical metabolism and the induction of oxidative stress. This review describes the metabolites isolated from Botrytis species, the spectroscopic data, grouping together by structural family, synthesis and chemical transformation, specially those carried out on botryane skeleton. The basic skeleton of botrydial is a bicyclic, non isoprenoid sesquiterpene system which has provided the stimulus for many investigations into the biosynthetic pathway to this skeleton. The biosynthetic studies carried out and the approaches to the asymmetric synthesis on this skeleton are reported in this paper. On the other hand, a detailed study on biological activity showed for these metabolites and the structure-activity relationship of metabolites with the botryanes skeleton is included.